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Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-05-1664. This Article Full Text (PDF) All Versions of this Article: 2003-05-1664v1 102/10/3483    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Herzog, E. L Articles by Krause, D. S Search for Related Content PubMed PubMed Citation Articles by Herzog, E. L Articles by Krause, D. S Social Bookmarking                   What's this? Submitted May 29, 2003 Accepted July 24, 2003 Plasticity of marrow derived stem cells Erica L Herzog, Li Chai, and Diane S Krause* Division of Pulmonary Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA * Corresponding author; email: diane.krause{at}yale.edu. Bone marrow (BM) contains hematopoietic stem cells (HSC), which differentiate into all mature blood cells, endothelial cells progenitors, and marrow stromal cells, also called mesenchymal stem cells (MSC), that can differentiate into mature cells of multiple mesenchymal tissues including fat, bone and cartilage. Recent findings indicate that adult BM also contains cells that can differentiate into additional mature, nonhematopoietic cells of multiple tissues including epithelial cells of the liver, kidney, lung, skin and GI tract and myocytes of heart and skeletal muscle. The experimental results obtained both in vitro and in vivo are the subject of this review. The emphasis is on how these experiments were performed, and under what conditions bone marrow to epithelial and neural cell differentiation occurs. Questions are raised regarding whether tissue injury is necessary for this differentiation and the mechanisms by which it occurs. Also considered are which bone marrow subpopulations are capable of this differentiation. Only after we better understand the mechanistic issues that govern this differentiation as well as the cells that are needed will we be able to fully harness this adult stem cell plasticity for clinical purposes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Haridass, Q. Yuan, P. D. Becker, T. Cantz, M. Iken, M. Rothe, N. Narain, M. Bock, M. Norder, N. Legrand, et al. 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