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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3233-3242. Prepublished online as a Blood First Edition Paper on June 15, 2004; DOI 10.1182/blood-2003-05-1679. This Article Full Text (PDF) All Versions of this Article: 2003-05-1679v1 104/10/3233    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, S.-C. Articles by Lin, R.-H. Search for Related Content PubMed PubMed Citation Articles by Chen, S.-C. Articles by Lin, R.-H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 29, 2003 Accepted May 17, 2004 Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells Shu-Ching Chen, Chiu-Chen Huang, Chung-Liang Chien, Chung-Jiuan Jeng, Ho-Ting Su, Evelyn Chiang, Meng-Ru Liu, C H Wu, Chung-Nan Chang, and Rong-Hwa Lin* Graduate Institute of Immunology, National Taiwan University, Taipei, Taiwan; AbGenomics Co., Taipei, Taiwan AbGenomics Co., Taipei, Taiwan Department of Anatomy and Cell Biology, National Taiwan University, Taipei, Taiwan Department of Medicine, FuJen Catholic University, Taipei, Taiwan; AbGenomics Co., Taipei, Taiwan * Corresponding author; email: rhlin{at}abgenomics.com. Increasing evidence has shown that death signaling in T cells is regulated in a very complicated way. Molecules other than death receptors can also trigger T-cell death. Here we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classical cell death, PSGL-1-mediated T cell death is caspase-independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1-mediated T-cell death. Collectively, this study demonstrates a novel role of PSGL-1 in controlling activated T-cell death and thus advances our understanding of immune regulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Urzainqui, G. Martinez del Hoyo, A. Lamana, H. de la Fuente, O. Barreiro, I. M. Olazabal, P. Martin, M. K. Wild, D. Vestweber, R. Gonzalez-Amaro, et al. Functional Role of P-Selectin Glycoprotein Ligand 1/P-Selectin Interaction in the Generation of Tolerogenic Dendritic Cells J. Immunol., December 1, 2007; 179(11): 7457 - 7465. [Abstract] [Full Text] [PDF] D. V. Ostanin, K. L. Furr, K. P. Pavlick, L. Gray, C. G. Kevil, D. Shukla, D. D'Souza, J. M. Hoffman, and M. B. Grisham T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1706 - G1714. [Abstract] [Full Text] [PDF] J. Rivera-Nieves, T. L. Burcin, T. S. Olson, M. A. Morris, M. McDuffie, F. Cominelli, and K. Ley Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis J. Exp. Med., April 17, 2006; 203(4): 907 - 917. [Abstract] [Full Text] [PDF] S. Dadsetan, V. Shishkin, and A. F. Fomina Intracellular Ca2+ Release Triggers Translocation of Membrane Marker FM1-43 from the Extracellular Leaflet of Plasma Membrane into Endoplasmic Reticulum in T Lymphocytes J. Biol. Chem., April 22, 2005; 280(16): 16377 - 16382. [Abstract] [Full Text] [PDF]

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