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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1370-1372. Prepublished online as a Blood First Edition Paper on October 23, 2003; DOI 10.1182/blood-2003-05-1701. This Article Full Text (PDF) All Versions of this Article: 2003-05-1701v1 103/4/1370    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Duan, L.-J. Articles by Fong, G.-H. Search for Related Content PubMed PubMed Citation Articles by Duan, L.-J. Articles by Fong, G.-H. Social Bookmarking                   What's this? Submitted May 29, 2003 Accepted October 14, 2003 Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization Li-Juan Duan, Akira Imamoto, and Guo-Hua Fong* Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA Center for Molecular Oncology, University of Chicago, Chicago, IL, USA * Corresponding author; email: fong{at}nso2.uchc.edu. Here we report that Csk, a tyrosine kinase that negatively regulates the activity of Src and related kinases, is important for vascular development. In Csk-/- embryos, while vascular tubules were formed and organized into capillary-like networks during the initial genesis of blood vessels, the vessels failed to engage in normal sprout formation. In chimeric embryos containing both wild type and Csk-/- cells, the presence of wild type cells enabled Csk-/- endothelial cells to participate in branching morphogenesis. We suggest that wild type cells may have supplied an angiogenic factor absent in Csk-/- cells. Despite the partial rescue of vascular development in chimeric embryos, the embryos failed to form vitelline vessels and died at E9.5. These results indicate that Csk is required both for angiogenic sprouting and vascular remodeling. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Mariappan, R. Niemann, M. Gajewski, J. Winkler, S. Chen, S. Choorapoikayil, M. Bitzer, H. Schulz, J. Hescheler, and A. Sachinidis Somitovasculin, a Novel Endothelial-Specific Transcript Involved in the Vasculature Development Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1823 - 1829. [Abstract] [Full Text] [PDF] L. Labrecque, C. Nyalendo, S. Langlois, Y. Durocher, C. Roghi, G. Murphy, D. Gingras, and R. Beliveau Src-mediated Tyrosine Phosphorylation of Caveolin-1 Induces Its Association with Membrane Type 1 Matrix Metalloproteinase J. Biol. Chem., December 10, 2004; 279(50): 52132 - 52140. [Abstract] [Full Text] [PDF]

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