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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2806-2808. Prepublished online as a Blood First Edition Paper on December 4, 2003; DOI 10.1182/blood-2003-06-1812. This Article Full Text (PDF) All Versions of this Article: 2003-06-1812v1 103/7/2806    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Annels, N. E Articles by Revesz, T. Search for Related Content PubMed PubMed Citation Articles by Annels, N. E Articles by Revesz, T. Social Bookmarking                   What's this? Submitted June 5, 2003 Accepted November 27, 2003 Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL Nicola E Annels*, Annemieke J Willemze, Vincent H J van der Velden, Claudia M J M Faaij, Elisabeth van Wering, Daisy M D S Sie-Go, R Maarten Egeler, Maarten J D van Tol, and Tom Revesz Department of Pediatrics, Leiden University Medical Centre, Leiden, The Netherlands Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands Dutch Childhood Oncology Group, The Hague, The Netherlands Department of Pathology, University Medical Centre, Utrecht, The Netherlands Department of Pediatric Haematology and Stem Cell Transplantation, University Medical Centre, Utrecht, The Netherlands * Corresponding author; email: n.e.annels{at}lumc.nl. Childhood acute lymphoblastic leukaemia (ALL) is often associated with extramedullary infiltration by leukaemic cells at diagnosis or at relapse. To understand the mechanisms behind the dissemination of T-ALL cells this study investigated the homing receptor expression on the blast cells of 11 paediatric T-ALL patients at diagnosis. One patient revealed a unique profile with high expression of the chemokine receptor CCR9 and the integrin CD103 on the T-ALL cells. Both these molecules are specifically associated with homing to the gut. This finding was clinically significant as the patient later suffered a relapse which was confined to the gut. Immunohistochemistry revealed that the leukaemic cells in the gut still expressed CCR9 and co-localized with a high expression of the CCR9 ligand, CCL25. These findings suggest that the original expression of CCR9 and CD103 on the leukaemic cells contributed to the relapse location in the gut of this patient. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Grueter, M. Petter, T. Egawa, K. Laule-Kilian, C. J. Aldrian, A. Wuerch, Y. Ludwig, H. Fukuyama, H. Wardemann, R. Waldschuetz, et al. Runx3 Regulates Integrin {alpha}E/CD103 and CD4 Expression during Development of CD4-/CD8+ T Cells J. Immunol., August 1, 2005; 175(3): 1694 - 1705. [Abstract] [Full Text] [PDF]

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