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Prepublished online as a Blood First Edition Paper on July 24, 2003; DOI 10.1182/blood-2003-06-1843. This Article Full Text (PDF) All Versions of this Article: 2003-06-1843v1 103/1/360    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Meignin, V. Articles by Socie, G. Search for Related Content PubMed PubMed Citation Articles by Meignin, V. Articles by Socie, G. Social Bookmarking                   What's this? Submitted June 13, 2003 Accepted July 13, 2003 Little evidence of donor-derived epithelial cells in early digestive acute graft versus host disease Veronique Meignin, Jean Soulier, Frederic Brau, Marc Lemann, Eliane Gluckman, Anne Janin, and Gerard Socie* INSERM ERM-0220, Paris, France; Service d'Hematologie Greffe de Moelle, Hospital St Louis, Paris, France Service de Pathologie, Hospital St Louis, Paris, France Laboratoire Central d'Hematologie, Hospital St Louis, Paris, France Service Commun d'Imagerie, Hospital St Louis, Paris, France Service d'Hepato-Gastroenterologie, Hospital St Louis, Paris, France * Corresponding author; email: gsocie{at}chu-stlouis.fr. Donor origin of epithelial intestinal cells has been studied in animals and humans after transplantation and has been used as evidence of hematopoietic stem cell (HSC) plasticity. However, in the human gastro-intestinal tract no study used X and Y-chromosome detection by fluorescence in situ hybridization (FISH) coupled with immunological stainings to characterize cell types on the same tissue section. We here combined these techniques on the same section of duodenal epithelium in 6 patients with acute graft versus host disease. Donor-derived lymphoid cells were detected both in the epithelium and lamina propria, as expected. However, no donor-derived cells could be proven to be of epithelial type, using our stringent criteria. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. C.W. Hung, T. K.F. Shing, S. S.C. Chim, P. C. Yeung, R. W.Y. Chan, K. W. Chik, V. Lee, N. B.Y. Tsui, C.-K. Li, C. S.C. Wong, et al. Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis Clin. Chem., April 1, 2009; 55(4): 715 - 722. [Abstract] [Full Text] [PDF] A. Janin, H. Murata, C. Leboeuf, J.-M. Cayuela, E. Gluckman, L. Legres, A. Desveaux, M. Varna, P. Ratajczak, J. Soulier, et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation Blood, February 19, 2009; 113(8): 1834 - 1840. [Abstract] [Full Text] [PDF] D. Imanishi, Y. Miyazaki, R. Yamasaki, Y. Sawayama, J. Taguchi, H. Tsushima, T. Fukushima, S. Yoshida, H. Sasaki, T. Hata, et al. Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem-cell transplants Blood, October 1, 2007; 110(7): 2231 - 2234. [Abstract] [Full Text] [PDF] H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie Donor-derived cells and human graft-versus-host disease of the skin Blood, March 15, 2007; 109(6): 2663 - 2665. [Abstract] [Full Text] [PDF]

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