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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2699-2704. Prepublished online as a Blood First Edition Paper on December 18, 2003; DOI 10.1182/blood-2003-06-1913. This Article Full Text (PDF) All Versions of this Article: 2003-06-1913v1 103/7/2699    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Castelli, J. Articles by Levy, J. A Search for Related Content PubMed PubMed Citation Articles by Castelli, J. Articles by Levy, J. A Social Bookmarking                   What's this? Submitted June 18, 2003 Accepted November 21, 2003 Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15 JoAnn Castelli, Elaine K Thomas, Michel Gilliet, Yong-Jun Liu, and Jay A Levy* Department of Medicine, University of California, San Francisco, San Francisco, CA, USA DNAX Corp., Palo Alto, CA, USA Immunex Corp., Seattle, WA, USA * Corresponding author; email: jalevy{at}itsa.ucsf.edu. The CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with a long-term healthy clinical state in HIV-infected individuals. Over time CNAR is reduced concomitant with progression to disease. In studies to evaluate whether the interaction between CD8+ cells and dendritic cells (DC) could increase CNAR, CD8+ cells from individuals who showed a decrease in this antiviral activity were co-cultured with monocyte-derived dendritic cells matured with CD40 ligand. After coculture with these mature DC, the CD8+ cells showed an increase in CNAR greater than that observed with CD8+ cells costimulated with CD3/CD28 antibodies. This antiviral response appeared to be mediated primarily by production of IL-15 by the mature DC. Purified IL-15 also enhanced CNAR, whereas IL-12 showed no substantial effect. These studies provide another potential approach by which the immune system in HIV infection could be restored by cytokine therapy, particularly IL-15 administration. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. R. Rodriguez, B. P. Arulanandam, V. L. Hodara, H. M. McClure, E. K. Cobb, M. T. Salas, R. White, and K. K. Murthy Influence of interleukin-15 on CD8+ natural killer cells in human immunodeficiency virus type 1-infected chimpanzees J. Gen. Virol., February 1, 2007; 88(2): 641 - 651. [Abstract] [Full Text] [PDF] T. A. Stoklasek, K. S. Schluns, and L. Lefrancois Combined IL-15/IL-15R{alpha} Immunotherapy Maximizes IL-15 Activity In Vivo J. Immunol., November 1, 2006; 177(9): 6072 - 6080. [Abstract] [Full Text] [PDF] L. S. Diaz, H. Foster, M. R. Stone, S. Fujimura, D. A. Relman, and J. A. Levy VCAM-1 Expression on CD8+ Cells Correlates with Enhanced Anti-HIV Suppressing Activity J. Immunol., February 1, 2005; 174(3): 1574 - 1579. [Abstract] [Full Text] [PDF] G. Ratzinger, J. Baggers, M. A. de Cos, J. Yuan, T. Dao, J. L. Reagan, C. Munz, G. Heller, and J. W. Young Mature Human Langerhans Cells Derived from CD34+ Hematopoietic Progenitors Stimulate Greater Cytolytic T Lymphocyte Activity in the Absence of Bioactive IL-12p70, by Either Single Peptide Presentation or Cross-Priming, Than Do Dermal-Interstitial or Monocyte-Derived Dendritic Cells J. Immunol., August 15, 2004; 173(4): 2780 - 2791. [Abstract] [Full Text] [PDF]

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