|
|
Blood, 1 March 2004, Vol. 103, No. 5, pp. 1934-1936.
Prepublished online as a Blood First Edition Paper on November 20, 2003; DOI 10.1182/blood-2003-06-1919.
Submitted June 16, 2003
Accepted October 9, 2003
Myocardial iron loading in transfusion-dependent thalassemia and sickle-cell disease
John C Wood*, J Michael Tyszka, Susan M Carson, Marvin D Nelson, and Thomas D Coates
Division of Pediatric Cardiology, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, CA, USA; Department of Biology, California Institute of Technology, Pasadena, CA, USA
Department of Pediatric Hematology, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, CA, USA
Department of Pediatric Radiology, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, CA, USA
* Corresponding author; email: jwood{at}chla.usc.edu.
Cardiac T2* is abnormal in approximately 40% of adults with thalassemia major (TM), suggesting myocardial iron deposition, but it is unknown at what age this occurs. To address this question, we measured cardiac T2* and function in 19 young (ages 7-26) TM patients as well as 17 chronically transfused sickle cell anemia (SCA) matched for age, sex, and liver iron content. Cardiac T2* was normal in all of the SCA patients but was low (high iron) in 8/19 TM patients. Abnormal T2* only observed in the TM patients transfused 13 years or more and was correlated with ferritin but not liver iron levels. Cardiac dysfunction was present in 3 of the 8 patients with low T2*. Cardiac T2* changes have a long latency relative to liver iron accumulation. Total transfusional burden is a significant independent risk factor for low cardiac T2* and may partially account for differences observed between SCA and TM patients.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Myocardial iron measurements by MRI: getting to the heart of the matter
- Ellis Neufeld
Blood 2004 103: 1571.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
P. Kirk, M. Roughton, J.B. Porter, J.M. Walker, M.A. Tanner, J. Patel, D. Wu, J. Taylor, M.A. Westwood, L.J. Anderson, et al.
Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major
Circulation,
November 17, 2009;
120(20):
1961 - 1968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Noetzli, J. Papudesi, T. D. Coates, and J. C. Wood
Pancreatic iron loading predicts cardiac iron loading in thalassemia major
Blood,
November 5, 2009;
114(19):
4021 - 4026.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Pepe, V Positano, M Capra, A Maggio, C L Pinto, A Spasiano, G Forni, G Derchi, B Favilli, G Rossi, et al.
Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major
Heart,
October 15, 2009;
95(20):
1688 - 1693.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ghoti, O. Goitein, E. Konen, A. Koren, C. Levin, A. Berebi, P. Stark, and E. Rachmilewitz
T2* MRI Provides No Evidence for Myocardial and Pancreatic Iron Overload in Multitransfused Patients with Sickle/{beta}-Thalassemia.
Blood (ASH Annual Meeting Abstracts),
November 16, 2008;
112(11):
1422 - 1422.
[Abstract]
|
|
|
|
|
|
|
L. J. Noetzli, S. M. Carson, A. S. Nord, T. D. Coates, and J. C. Wood
Longitudinal analysis of heart and liver iron in thalassemia major
Blood,
October 1, 2008;
112(7):
2973 - 2978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Leonardi, R. Margossian, S. D. Colan, and A. J. Powell
Relationship of magnetic resonance imaging estimation of myocardial iron to left ventricular systolic and diastolic function in thalassemia.
J. Am. Coll. Cardiol. Img.,
September 1, 2008;
1(5):
572 - 578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Wood, R. Origa, A. Agus, G. Matta, T. D. Coates, and R. Galanello
Onset of cardiac iron loading in pediatric patients with thalassemia major
Haematologica,
June 1, 2008;
93(6):
917 - 920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Angelucci, G. Barosi, C. Camaschella, M. D. Cappellini, M. Cazzola, R. Galanello, M. Marchetti, A. Piga, and S. Tura
Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders
Haematologica,
May 1, 2008;
93(5):
741 - 752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Li, T. Coates, and J. C. Wood
Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major
Haematologica,
February 1, 2008;
93(2):
311 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.A. Tanner, R. Galanello, C. Dessi, G.C. Smith, M.A. Westwood, A. Agus, M. Roughton, R. Assomull, S.V. Nair, J.M. Walker, et al.
A Randomized, Placebo-Controlled, Double-Blind Trial of the Effect of Combined Therapy With Deferoxamine and Deferiprone on Myocardial Iron in Thalassemia Major Using Cardiovascular Magnetic Resonance
Circulation,
April 10, 2007;
115(14):
1876 - 1884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Pennell, V. Berdoukas, M. Karagiorga, V. Ladis, A. Piga, A. Aessopos, E. D. Gotsis, M. A. Tanner, G. C. Smith, M. A. Westwood, et al.
Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
Blood,
May 1, 2006;
107(9):
3738 - 3744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Neufeld
Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions
Blood,
May 1, 2006;
107(9):
3436 - 3441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Wood, M. Otto-Duessel, M. Aguilar, H. Nick, M. D. Nelson, T. D. Coates, H. Pollack, and R. Moats
Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of Iron Cardiomyopathy
Circulation,
July 26, 2005;
112(4):
535 - 543.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cohen, R. Galanello, D. J. Pennell, M. J. Cunningham, and E. Vichinsky
Thalassemia
Hematology,
January 1, 2004;
2004(1):
14 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
