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Blood, 1 August 2004, Vol. 104, No. 3, pp. 626-633. Prepublished online as a Blood First Edition Paper on February 24, 2004; DOI 10.1182/blood-2003-06-2094. This Article Full Text (PDF) All Versions of this Article: 2003-06-2094v1 104/3/626    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pfreundschuh, M. Articles by Loeffler, M. Search for Related Content PubMed PubMed Citation Articles by Pfreundschuh, M. Articles by Loeffler, M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted June 26, 2003 Accepted February 8, 2004 2-weekly or 3-weekly CHOP Chemotherapy with or without etoposide for the Treatment of Young Patients with Good Prognosis (Normal LDH) Aggressive Lymphomas: Results of the NHL-B1 trial of the DSHNHL Michael Pfreundschuh*, Lorenz Truemper, Marita Kloess, Rudolf Schmits, Alfred C Feller, Christian Rudolph, Marcel Reiser, Dieter K Hossfeld, Bernd Metzner, Dirk Hasenclever, Norbert Schmitz, Bertram Glass, Christian Ruebe, and Markus Loeffler Saarland University Medical School, Homburg, Saarland, Germany Hematology, Universitatsklinikum Gottingen, Gottingen, Niedersachsen, Germany IMISE, Universitat Leipzig, Leipzig, Sachsen, Germany Institut fur Pathologie, Universitatsklinikum Schleswig-Holstein, Campus Lubeck, Lubeck, Schleswig-Holstein, Germany Klinikum Cottbus, Cottbus, Sachsen, Germany Med. Klinik, Universitatsklinikum Koeln, Koeln, Nord-Rhein-Westfalen, Germany Onkologie, Universitatsklinikum Eppendorf, Hamburg, Germany Onkologie, Klinikum Oldenburg, Oldenburg, Niedersachsen, Germany Haematologie, Krankenhaus St. Georg, Hamburg, Germany * Corresponding author; email: michael.pfreundschuh{at}uniklinik-saarland.de. The combination of cyclophosphamide, doxorubicin, vincristine, and prednisone, given every 3 weeks (CHOP-21) is standard chemotherapy for aggressive lymphomas. To determine whether CHOP given every 2 weeks (CHOP-14) and/or the addition of etoposide (CHOEP-21, CHOEP-14) can improve results in patients aged 18-60 years with good prognosis (normal LDH), 710 patients were randomized to 6 cycles of CHOP-21, CHOP-14, CHOEP-21 (CHOP plus etoposide 100 mg/m2 d1-d3), or CHOEP-14 in a 2x2 factorial study design. Patients in the 2-weekly regimens received G-CSF starting from day 4. Patients received radiotherapy (36 Gy) to sites of initial bulky disease and extranodal disease. CHOEP achieved a better complete remission (87.6% vs. 79.4%; p=0.003) and 5-year event-free survival rate (69.2% vs. 57.6%; p=0.004, primary endpoint) than CHOP, while interval reduction improved overall survival (p=0.05; p=0.044 in the multivariate analysis). While the CHOEP regimens induced more myelosuppression, all regimens were well tolerated. CHOEP should be the preferred chemotherapy regimen for young patients with good prognosis (normal LDH) aggressive lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Is more better? David Linch Blood 2004 104: 596-597. [Full Text] [PDF] This article has been cited by other articles: H.-W. Bernd, M. Ziepert, C. Thorns, W. Klapper, H.-H. Wacker, M. Hummel, H. Stein, M.-L. Hansmann, G. Ott, A. Rosenwald, et al. 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