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Blood, 1 August 2004, Vol. 104, No. 3, pp. 634-641. Prepublished online as a Blood First Edition Paper on March 11, 2004; DOI 10.1182/blood-2003-06-2095. This Article Full Text (PDF) All Versions of this Article: 2003-06-2095v1 104/3/634    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pfreundschuh, M. Articles by Loeffler, M. Search for Related Content PubMed PubMed Citation Articles by Pfreundschuh, M. Articles by Loeffler, M. Related Collections Related Article in Blood Online Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 9, 2003 Accepted February 10, 2004 2-weekly or 3-weekly CHOP Chemotherapy with or without Etoposide for the Treatment of Elderly Patients with Aggressive Lymphomas: Results of the NHL-B2 trial of the DSHNHL Michael Pfreundschuh*, Lorenz Truemper, Marita Kloess, Rudolph Schmits, Alfred C Feller, Christian Ruebe, Christian Rudolph, Marcel Reiser, Dieter K Hossfeld, Hartmut Eimermacher, Dirk Hasenclever, Norbert Schmitz, and Markus Loeffler Saarland University Medical School, Homburg, Saar, Germany Haematologie/Onkologie, Universitatsklinikum Gottingen, Gottingen, Niedersachsen, Germany IMISE, Universitat Leipzig, Leipzig, Sachsen, Germany Klinikum Cottbus, Cottbus, Sachsen, Germany Med. Klinik, Universitatsklinik Koeln, Koeln, Nordrhein-Westfalen, Germany Onkologie, Universitatsklinikum Eppendrof, Hamburg, Germany St.-Marien-Hospital, Hagen, Nordrehin-Westfalen, Germany Haematologie, St.-Georgs-Krankenhaus, Hamburg, Germany * Corresponding author; email: michael.pfreundschuh{at}uniklinik-saarland.de. Cyclophosphamide, doxorubicin, vincristine and prednisone, given every 3 weeks (CHOP-21) is standard chemotherapy for aggressive lymphomas. To determine whether bi-weekly CHOP (CHOP-14) with or without etoposide is more effective than CHOP-21, six-hundred-and-eighty-nine patients aged 61-75 years were randomized to 6 cycles of CHOP-21, CHOP-14, CHOEP-21 (CHOP plus etoposide 100 mg/m2 d1-d3), or CHOEP-14. Patients in the 2-weekly regimens received G-CSF starting from day 4. Patients received radiotherapy (36 Gy) to sites of initial bulky disease and extranodal disease. Complete remission rates were 60.1% (CHOP-21), 70.0% (CHOEP-21), 76.1% (CHOP-14) and 71.6% (CHOEP-14), respectively. Five-year event-free and overall survival rates were 32.5% and 40.6%, respectively, for CHOP-21, and 43.8% and 53.3%, respectively, for CHOP-14. In a multivariate analysis the relative risk reduction was 0.66 (p=0.003) for event-free and 0.58 (p<0.001) for overall survival after CHOP-14 compared to CHOP-21. Toxicity of CHOP-14 and CHOP-21 was similar, but CHOEP-21 and in particular CHOEP-14 were more toxic. Due to its favorable efficacy and toxicity profile, CHOP-14 should be considered the new standard chemotherapy regimen for patients with aggressive lymphoma aged over 60. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Is more better? David Linch Blood 2004 104: 596-597. [Full Text] [PDF] Related Letter in Blood Online: Immunochemotherapy is the standard of care in elderly patients with diffuse large B-cell lymphoma Bertrand Coiffier, Gilles Salles, Michael Pfreundschuh, and Markus Loeffler Blood 2004 104: 1584-1586. [Full Text] [PDF] This article has been cited by other articles: C. Haioun, N. Mounier, J. F. Emile, D. Ranta, B. Coiffier, H. Tilly, C. Recher, C. Ferme, J. Gabarre, R. Herbrecht, et al. Rituximab versus observation after high-dose consolidative first-line chemotherapy with autologous stem-cell transplantation in patients with poor-risk diffuse large B-cell lymphoma Ann. Onc., December 1, 2009; 20(12): 1985 - 1992. [Abstract] [Full Text] [PDF] H.-W. Bernd, M. Ziepert, C. Thorns, W. Klapper, H.-H. Wacker, M. Hummel, H. Stein, M.-L. Hansmann, G. Ott, A. Rosenwald, et al. 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Metzner, D. Hasenclever, et al. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL Blood, August 1, 2004; 104(3): 626 - 633. [Abstract] [Full Text] [PDF]

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