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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3265-3270. Prepublished online as a Blood First Edition Paper on December 18, 2003; DOI 10.1182/blood-2003-06-2124. This Article Full Text (PDF) All Versions of this Article: 2003-06-2124v1 103/9/3265    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Howe, R. B Articles by Hellstrom-Lindberg, E. Search for Related Content PubMed PubMed Citation Articles by Howe, R. B Articles by Hellstrom-Lindberg, E. Social Bookmarking                   What's this? Submitted June 27, 2003 Accepted November 27, 2003 The WHO classification of MDS does make a difference Robert B Howe*, Anna Porwit-MacDonald, Robert Wanat, Ramin Tehranchi, and Eva Hellstrom-Lindberg Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA Department of Pathology, Karolinska Hospital and Institute, Stockholm, Sweden Department of Medicine, Huddinge University Hospital and Karolinska Institute, Stockholm, Sweden * Corresponding author; email: howex001{at}umn.edu. The purpose of this study was to determine the facility and reliability of the WHO classification of myelodysplastic syndromes (MDS) with several observers reviewing the same diagnostic specimens. We also wanted to determine if the WHO classification provided additional information about predictability of clinical response outcome. To accomplish these goals we reviewed 103 previously diagnosed cases of low-risk MDS. We found 92% inter-observer agreement (p<0.001). Sixty-four of these patients had been entered into clinical trials using growth factors by the Nordic MDS Study Group. The WHO classification reliably predicted therapeutic response to the combination of Granulocyte Colony-stimulating-factor (G-CSF) and erythropoietin (Epo). The response rate differed significantly between refractory anemia with ringed sideroblasts (RARS) and refractory anemia with multilineage dysplasia and ringed sideroblasts (RCMD/RS) with regard to therapeutic response (75% vs. 9%, p=0.003). Also, in the group of patients with <5% marrow blasts, there was a difference in median survival between patients with unilineage dysplasia (51% surviving at 67 months) and those with multilineage dysplasia (median survival 28.5 months, p=0.03). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. L. Greenberg, Z. Sun, K. B. Miller, J. M. 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