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Prepublished online as a Blood First Edition Paper on August 28, 2003; DOI 10.1182/blood-2003-07-2236. This Article Full Text (PDF) All Versions of this Article: 2003-07-2236v1 103/2/435    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blaise, D. P Articles by Viens, P. Search for Related Content PubMed PubMed Citation Articles by Blaise, D. P Articles by Viens, P. Social Bookmarking                   What's this? Submitted July 7, 2003 Accepted August 26, 2003 Reduced intensity preparative regimen and allogeneic stem cell transplantation for advanced solid tumors Didier P Blaise*, Jacques Olivier Bay, Catherine Faucher, Mauricette Michallet, Jean-Michel Boiron, Bachra Choufi, Jean-Yves Cahn, Nicole Gratecos, Jean-Jacques Sotto, Sylvie Francois, Joel Fleury, Mohamad Mohty, Christian Chabannon, Karin Bilger, Gwenaelle Gravis, Frederic Viret, Anne Chantal Braud, Valerie Jeanne Bardou, Dominique Maraninchi, and Patrice Viens Unite de Transplantation et de Therapie Cellulaire, Institut Paoli Calmettes, Marseille, France; Universite de la Mediterranee, Marseille, France; Centre d'Investigation Clinique, Hopital Ste Marguerite, Marseille, France Centre Jean Perrin, Clermont-Ferrand, France CHU Edouard Herriot, Lyon, France CHU Haut Leveque, Bordeaux, France CHU Jean Minjoz, Besancon, France CHU Cimiez, Nice, France CHU Michalon, Grenoble, France CHU Angers, Angers, France Departement d'Oncologie Medicale, Institut Paoli Calmettes, Marseille, France Unite de Biostatistiques, Institut Paoli Calmettes, Marseille, France * Corresponding author; email: blaised{at}marseille.fnclcc.fr. In this prospective multicenter program, we investigated allogeneic stem cell transplantation (ASCT) from HLA-identical siblings following reduced intensity conditioning regimen (RIC) for patients with refractory metastatic solid tumors (ST). Fifty seven patients, of whom 39 had a progressive disease (PD) at time of ASCT, received a RIC ASCT combining fludarabine, anti-thymocyte globulin (ATG) and busulfan. Patients were analyzed in terms of engraftment, transplant related mortality (TRM), disease response and outcome. In this setting, RIC was associated with rapid engraftment and low overall TRM (9 % (95%CI, 1-16)). The cumulative incidence of objective responses (OR) reached 14% (95%CI, 6-30) with this being significantly higher in patients without PD (44% (95%CI, 21-67) vs. 0; P<0.0001) at time of ASCT. Achievement of OR translated into a significantly better overall survival (OS). In multivariate analysis, OS was significantly influenced by disease status at time of ASCT (odds ratio, 4.88; P<.001) and chronic GVHD occurrence (odds ratio, 2.86; P<0.01). Overall, these results showed that OR can occur after RIC ASCT for resistant ST with a relatively low TRM and potential benefit especially in patients with slowly progressive disease. Further studies are warranted in patients with less advanced ST. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. S. Tykodi, N. Fujii, N. Vigneron, S. M. Lu, J. K. Mito, M. X. Miranda, J. Chou, L. N. Voong, J. A. Thompson, B. M. Sandmaier, et al. C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8+ Cytotoxic T Cells from Renal Cell Carcinoma Patients Clin. Cancer Res., August 15, 2008; 14(16): 5260 - 5269. [Abstract] [Full Text] [PDF] D. Sangiolo, E. Martinuzzi, M. Todorovic, K. Vitaggio, A. Vallario, N. Jordaney, F. 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