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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3511-3515. Prepublished online as a Blood First Edition Paper on January 15, 2004; DOI 10.1182/blood-2003-07-2254. This Article Full Text (PDF) All Versions of this Article: 2003-07-2254v1 103/9/3511    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jundt, F. Articles by Doerken, B. Search for Related Content PubMed PubMed Citation Articles by Jundt, F. Articles by Doerken, B. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted July 7, 2003 Accepted December 19, 2003 Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells Franziska Jundt*, Kristina Schulze Proebsting, Ioannis Anagnostopoulos, Gwendolin Muehlinghaus, Manik Chatterjee, Stephan Mathas, Ralf C Bargou, Rudolf Manz, Harald Stein, and Bernd Doerken Department of Hematology and Oncology, Charite, Campus Virchow-Klinikum, University Medicine Berlin, Berlin, Germany; Max-Delbrueck Center of Molecular Medicine, Berlin, Germany Institute of Pathology, Charite, Campus Benjamin Franklin, University Medicine Berlin, Berlin, Germany Deutsches Rheumaforschungszentrum, Berlin, Germany * Corresponding author; email: fjundt{at}mdc-berlin.de. Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival. We recently demonstrated that Notch signaling is involved in proliferation and survival of B-cell-derived tumor cells of classic Hodgkin disease and described a novel mechanism for the oncogenic capacity of Notch. In this study we investigated whether Notch signaling is involved in the tight interactions between neoplastic plasma cells and their bone marrow microenvironment, that are essential for tumor cell growth in multiple myeloma (MM). Here we demonstrate that Notch receptors and their ligand Jagged1 are highly expressed in cultured and primary MM cells, whereas non-neoplastic counterparts show low to undetectable levels of Notch. Functional data indicate that ligand-induced Notch signaling is a growth factor for MM cells and suggest that these interactions contribute to myelomagenesis in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Notch signaling: a key to the pathogenesis of multiple myeloma? Laurie A. Milner Blood 2004 103: 3253-3254. [Full Text] [PDF] This article has been cited by other articles: B. Nervi, P. Ramirez, M. P. Rettig, G. L. Uy, M. S. Holt, J. K. Ritchey, J. L. Prior, D. Piwnica-Worms, G. Bridger, T. J. Ley, et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100 Blood, June 11, 2009; 113(24): 6206 - 6214. [Abstract] [Full Text] [PDF] H. Kohlhof, F. Hampel, R. Hoffmann, H. Burtscher, U. H. Weidle, M. Holzel, D. Eick, U. Zimber-Strobl, and L. J. Strobl Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells Blood, May 28, 2009; 113(22): 5506 - 5515. [Abstract] [Full Text] [PDF] X. Xiao, L. Ning, and H. Chen Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors Mol. Cancer Ther., February 1, 2009; 8(2): 350 - 356. [Abstract] [Full Text] [PDF] D.-M. Shin, D. J. Shaffer, H. Wang, D. C. Roopenian, and H. C. Morse III NOTCH Is Part of the Transcriptional Network Regulating Cell Growth and Survival in Mouse Plasmacytomas Cancer Res., November 15, 2008; 68(22): 9202 - 9211. [Abstract] [Full Text] [PDF] C. A. Huff and W. Matsui Multiple Myeloma Cancer Stem Cells J. Clin. Oncol., June 10, 2008; 26(17): 2895 - 2900. [Abstract] [Full Text] [PDF] M. B. Meads, L. A. Hazlehurst, and W. S. Dalton The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance Clin. Cancer Res., May 1, 2008; 14(9): 2519 - 2526. [Abstract] [Full Text] [PDF] Y. Nefedova, D. M. Sullivan, S. C. Bolick, W. S. Dalton, and D. I. Gabrilovich Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy Blood, February 15, 2008; 111(4): 2220 - 2229. [Abstract] [Full Text] [PDF] D. LeBrun, T. Baetz, C. Foster, P. Farmer, R. Sidhu, H. Guo, K. Harrison, R. Somogyi, L. D. Greller, and H. Feilotter Predicting Outcome in Follicular Lymphoma by Using Interactive Gene Pairs Clin. Cancer Res., January 15, 2008; 14(2): 478 - 487. [Abstract] [Full Text] [PDF] V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF] M. Kunnimalaiyaan and H. Chen Tumor Suppressor Role of Notch-1 Signaling in Neuroendocrine Tumors Oncologist, May 1, 2007; 12(5): 535 - 542. [Abstract] [Full Text] [PDF] K. G. Leong and A. Karsan Recent insights into the role of Notch signaling in tumorigenesis Blood, March 15, 2006; 107(6): 2223 - 2233. [Abstract] [Full Text] [PDF] P. A. Zweidler-McKay, Y. He, L. Xu, C. G. Rodriguez, F. G. Karnell, A. C. Carpenter, J. C. Aster, D. Allman, and W. S. Pear Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies Blood, December 1, 2005; 106(12): 3898 - 3906. [Abstract] [Full Text] [PDF] M. Reedijk, S. Odorcic, L. Chang, H. Zhang, N. Miller, D. R. McCready, G. Lockwood, and S. E. Egan High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival Cancer Res., September 15, 2005; 65(18): 8530 - 8537. [Abstract] [Full Text] [PDF] B. Quesnel Multiple myeloma: all roads lead to cyclin D Blood, July 1, 2005; 106(1): 1 - 2. [Full Text] [PDF] A. A. Jungbluth, S. Ely, M. DiLiberto, R. Niesvizky, B. Williamson, D. Frosina, Y.-T. Chen, N. Bhardwaj, S. Chen-Kiang, L. J. Old, et al. The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation Blood, July 1, 2005; 106(1): 167 - 174. [Abstract] [Full Text] [PDF] T. Takeuchi, Y. Adachi, and Y. Ohtsuki Skeletrophin, a Novel Ubiquitin Ligase to the Intracellular Region of Jagged-2, Is Aberrantly Expressed in Multiple Myeloma Am. J. Pathol., June 1, 2005; 166(6): 1817 - 1826. [Abstract] [Full Text] [PDF] L. Yin Chondroitin Synthase 1 Is a Key Molecule in Myeloma Cell-Osteoclast Interactions J. Biol. Chem., April 22, 2005; 280(16): 15666 - 15672. [Abstract] [Full Text] [PDF] T. Matsumoto and M. Abe The Importance of Notch Signaling in Myeloma Cell-Osteoclast Interactions IBMS BoneKEy, February 1, 2005; 2(2): 7 - 10. [Full Text] [PDF] C. Houde, Y. Li, L. Song, K. Barton, Q. Zhang, J. Godwin, S. Nand, A. Toor, S. Alkan, N. V. Smadja, et al. Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines Blood, December 1, 2004; 104(12): 3697 - 3704. [Abstract] [Full Text] [PDF] F. Jundt, O. Acikgoez, R. Preissner, and B. Dorken Manipulation of the Notch Pathway by {gamma}-Secretase Inhibitors as a Novel Therapeutic Approach in Multiple Myeloma. Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 645 - 645. [Abstract]

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