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Prepublished online as a Blood First Edition Paper on August 21, 2003; DOI 10.1182/blood-2003-07-2420. This Article Full Text (PDF) All Versions of this Article: 2003-07-2420v1 103/2/489    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ooi, J. Articles by Asano, S. Search for Related Content PubMed PubMed Citation Articles by Ooi, J. Articles by Asano, S. Social Bookmarking                   What's this? Submitted July 18, 2003 Accepted August 16, 2003 Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia Jun Ooi*, Tohru Iseki, Satoshi Takahashi, Akira Tomonari, Kashiya Takasugi, Yoko Shimohakamada, Toshiki Yamada, Koji Ishii, Nobuhiro Ohno, Fumitaka Nagamura, Kaoru Uchimaru, Arinobu Tojo, and Shigetaka Asano Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan * Corresponding author; email: jun-ooi{at}ims.u-tokyo.ac.jp. We report the results of unrelated cord blood transplantation (CBT) for 18 adult patients with de novo acute myeloid leukemia (AML). The median age was 43 years, the median weight was 55.2 kg, and the median number of cryopreserved nucleated cells was 2.51 x 107/kg. Seventeen patients had myeloid reconstitution and the median time to more than 0.5 x 109/L absolute neutrophil count was 23 days. A self-sustained platelet count more than 50 x 109/L was achieved in 16 patients at a median time of 49 days. Acute graft-versus-host disease (GVHD) above grade II occurred in 11 of 17 evaluable patients and chronic GVHD in 14 of 17 evaluable patients. Fourteen patients are alive and free of disease at between 185 and 1332 days after transplantation. The probability of disease-free survival at 2 years was 76.6%. These results suggest that adult AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. G. Brunstein, J. N. Barker, D. J. Weisdorf, T. E. DeFor, J. S. Miller, B. R. Blazar, P. B. McGlave, and J. E. Wagner Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease Blood, October 15, 2007; 110(8): 3064 - 3070. [Abstract] [Full Text] [PDF] Section on Hematology/Oncology and Section on Alle Cord Blood Banking for Potential Future Transplantation Pediatrics, January 1, 2007; 119(1): 165 - 170. [Abstract] [Full Text] [PDF] N. J. Chao Umbilical Cord Blood: Biology and Transplantation Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 329 - 333. [Full Text] [PDF] K. K. Ballen New trends in umbilical cord blood transplantation Blood, May 15, 2005; 105(10): 3786 - 3792. [Abstract] [Full Text] [PDF] S. Takahashi, T. Iseki, J. Ooi, A. Tomonari, K. Takasugi, Y. Shimohakamada, T. Yamada, K. Uchimaru, A. Tojo, N. Shirafuji, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies Blood, December 1, 2004; 104(12): 3813 - 3820. [Abstract] [Full Text] [PDF] T. Ichinohe, T. Uchiyama, C. Shimazaki, K. Matsuo, S. Tamaki, M. Hino, A. Watanabe, M. Hamaguchi, S. Adachi, H. Gondo, et al. Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism Blood, December 1, 2004; 104(12): 3821 - 3828. [Abstract] [Full Text] [PDF] V. Rocha, M. Labopin, G. Sanz, W. Arcese, R. Schwerdtfeger, A. Bosi, N. Jacobsen, T. Ruutu, M. de Lima, J. Finke, et al. Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia N. Engl. J. Med., November 25, 2004; 351(22): 2276 - 2285. [Abstract] [Full Text] [PDF] M. A. Sanz Cord-Blood Transplantation in Patients with Leukemia -- A Real Alternative for Adults N. Engl. J. Med., November 25, 2004; 351(22): 2328 - 2330. [Full Text] [PDF] N. J. Chao, S. G. Emerson, and K. I. Weinberg Stem Cell Transplantation (Cord Blood Transplants) Hematology, January 1, 2004; 2004(1): 354 - 371. [Abstract] [Full Text] [PDF]

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