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Blood, 1 August 2004, Vol. 104, No. 3, pp. 810-814. Prepublished online as a Blood First Edition Paper on April 13, 2004April 8, 2004; DOI 10.1182/blood-2003-07-2533. This Article Full Text (PDF) All Versions of this Article: 2003-07-2533v1 2003-07-2533v2 104/3/810    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Aoki, Y. Articles by Giovanna, T. Search for Related Content PubMed PubMed Citation Articles by Aoki, Y. Articles by Giovanna, T. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 25, 2003 Accepted March 26, 2004 HIV-1 Tat enhances KSHV infectivity Yoshiyasu Aoki* and Tosato Giovanna Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, USA * Corresponding author; email: aokiy{at}mail.nih.gov. The high frequency of Kaposi's sarcoma (KS) in immunodeficiency states, particularly in patients with AIDS, has been attributed to increased replication of KS-associated herpesvirus (KSHV), a necessary cofactor for KS development. However, experimental KSHV infection of endothelial lineage cells that compose KS lesions has been difficult even in the absence of immune cells. Here we show that HIV-1 Tat protein can directly promote KSHV transmission. Full-length HIV-1 Tat and a 13-amino-acid peptide corresponding to the basic region of Tat specifically enhances the entry of KSHV into endothelial and other cells, presenting evidence for an active role of HIV-1 in the development of KSHV-associated diseases. These results can explain why AIDS-KS is more frequent and clinically more aggressive than KS in other immunodeficiency states. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Kuang, Q. Tang, G. G. Maul, and F. Zhu Activation of p90 Ribosomal S6 Kinase by ORF45 of Kaposi's Sarcoma-Associated Herpesvirus and Its Role in Viral Lytic Replication J. Virol., February 15, 2008; 82(4): 1838 - 1850. [Abstract] [Full Text] [PDF] X. Zhang, J. F. Wang, G. Kunos, and J. E. Groopman Cannabinoid Modulation of Kaposi's Sarcoma Associated Herpesvirus Infection and Transformation Cancer Res., August 1, 2007; 67(15): 7230 - 7237. [Abstract] [Full Text] [PDF] J. A. R. Kaleeba and E. A. Berger Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. Science, March 31, 2006; 311(5769): 1921 - 1924. [Abstract] [Full Text] [PDF] H. G. Jorgensen, M. Copland, E. K. Allan, X. Jiang, A. Eaves, C. Eaves, and T. L. Holyoake Intermittent Exposure of Primitive Quiescent Chronic Myeloid Leukemia Cells to Granulocyte-Colony Stimulating Factor In vitro Promotes their Elimination by Imatinib Mesylate Clin. Cancer Res., January 15, 2006; 12(2): 626 - 633. [Abstract] [Full Text] [PDF] E. Caselli, M. Galvan, E. Cassai, A. Caruso, L. Sighinolfi, and D. Di Luca Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells Blood, October 15, 2005; 106(8): 2790 - 2797. [Abstract] [Full Text] [PDF] S. Marchio, M. Alfano, L. Primo, D. Gramaglia, L. Butini, L. Gennero, E. De Vivo, W. Arap, M. Giacca, R. Pasqualini, et al. Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein Blood, April 1, 2005; 105(7): 2802 - 2811. [Abstract] [Full Text] [PDF]

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