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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1909-1911. Prepublished online as a Blood First Edition Paper on November 6, 2003; DOI 10.1182/blood-2003-07-2577. This Article Full Text (PDF) Supplemental Data All Versions of this Article: 2003-07-2577v1 103/5/1909    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ferrando, A. A Articles by Look, A T Search for Related Content PubMed PubMed Citation Articles by Ferrando, A. A Articles by Look, A T Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted July 29, 2003 Accepted October 20, 2003 Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia Adolfo A Ferrando, Sabine Herblot, Teresa Palomero, Mark Hansen, Trang Hoang, Edward A Fox, and A T Look* Pediatric Oncology Department, Dana-Farber Cancer Institute, Boston, MA, USA Clinical Research Institute of Montreal, Montreal, PQ, Canada Shannon McCormack Advanced Molecular Diagnostics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA * Corresponding author; email: thomas_look{at}dfci.harvard.edu. Aberrant expression of transcription factor oncogenes such as HOX11, HOX11L2,TAL1/SCL, LYL1, LMO1 and LMO2 can be detected in lymphoblasts from up to 80% of patients with acute T-cell lymphoblastic leukemia (T-ALL). Transcriptional activation of these oncogenes in leukemic cells typically results from chromosomal rearrangements that place them next to highly active cis-acting transcriptional regulatory elements. However, biallelic activation of TAL1 in some T-ALL cases has been previously proposed. We have used allele-specific mRNA analysis to show that trans-acting mechanisms leading to biallelic over-expression of TAL1 are involved in 10 of 24 (42%) TAL1+ informative T-ALL cases, 2 of 12 (17%) HOX11+ informative cases and 7 of 11 (64%) LMO2+ informative cases. We propose that aberrant expression of oncogenic transcription factors in a significant fraction of T-ALLs may result from loss of the upstream transcriptional mechanisms that normally down-regulate the expression of these oncogenes during T-cell development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: T-ALL: smoking guns and genes of interest Peter D. Aplan Blood 2004 103: 1568-1569. [Full Text] [PDF] This article has been cited by other articles: K. Cullion, K. M. Draheim, N. Hermance, J. Tammam, V. M. Sharma, C. Ware, G. Nikov, V. Krishnamoorthy, P. K. Majumder, and M. A. Kelliher Targeting the Notch1 and mTOR pathways in a mouse T-ALL model Blood, June 11, 2009; 113(24): 6172 - 6181. [Abstract] [Full Text] [PDF] M. T. Kassouf, H. Chagraoui, P. Vyas, and C. Porcher Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis Blood, August 15, 2008; 112(4): 1056 - 1067. [Abstract] [Full Text] [PDF] S. Borghini, M. Vargiolu, M. Di Duca, R. Ravazzolo, and I. Ceccherini Nuclear Factor Y Drives Basal Transcription of the Human TLX3, a Gene Overexpressed in T-Cell Acute Lymphocytic Leukemia Mol. Cancer Res., September 1, 2006; 4(9): 635 - 643. [Abstract] [Full Text] [PDF] J. Soulier, E. Clappier, J.-M. Cayuela, A. Regnault, M. Garcia-Peydro, H. Dombret, A. Baruchel, M.-L. Toribio, and F. Sigaux HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL) Blood, July 1, 2005; 106(1): 274 - 286. [Abstract] [Full Text] [PDF] S. Tabrizifard, A. Olaru, J. Plotkin, M. Fallahi-Sichani, F. Livak, and H. T. Petrie Analysis of Transcription Factor Expression during Discrete Stages of Postnatal Thymocyte Differentiation J. Immunol., July 15, 2004; 173(2): 1094 - 1102. [Abstract] [Full Text] [PDF]

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