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Blood, 15 March 2004, Vol. 103, No. 6, pp. 2404-2406. Prepublished online as a Blood First Edition Paper on November 13, 2003; DOI 10.1182/blood-2003-08-2692. This Article Full Text (PDF) All Versions of this Article: 2003-08-2692v1 103/6/2404    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Parker, P. D Articles by Klonis, N. Search for Related Content PubMed PubMed Citation Articles by Parker, P. D Articles by Klonis, N. Social Bookmarking                   What's this? Submitted August 6, 2003 Accepted October 29, 2003 Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth Phillip D Parker, Leann Tilley, and Nectarios Klonis* Department of Biochemistry, La Trobe University, Melbourne, VIC, Australia; Cooperative Research Center for Diagnostics, La Trobe University, Melbourne, VIC, Australia * Corresponding author; email: N.Klonis{at}latrobe.edu.au. The virulence of the malaria parasite, Plasmodium falciparum, is due in large part to the way in which it modifies the membrane of its erythrocyte host. In this work we have used confocal microscopy and fluorescence recovery after photobleaching to examine the lateral mobility of host membrane proteins in erythrocytes infected with P. falciparum at different stages of parasite growth. The erythrocyte membrane proteins band 3 and glycophorin show a marked decrease in mobility during the trophozoite stage of growth. Erythrocytes infected with a parasite strain that does not express the knob-associated histidine-rich protein show similar effects indicating that this parasite protein does not contribute to the immobilization of the host proteins. Erythrocytes infected with ring stage parasites exhibit intermediate mobilities indicating that the parasite is able to modify its host prior to its active feeding-stage. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Rug, S. W. Prescott, K. M. Fernandez, B. M. Cooke, and A. F. Cowman The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes Blood, July 1, 2006; 108(1): 370 - 378. [Abstract] [Full Text] [PDF] P. Horrocks, R. A. Pinches, S. J. Chakravorty, J. Papakrivos, Z. Christodoulou, S. A. Kyes, B. C. Urban, D. J. P. Ferguson, and C. I. Newbold PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes J. Cell Sci., June 1, 2005; 118(11): 2507 - 2518. [Abstract] [Full Text] [PDF]

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