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Blood, 15 April 2004, Vol. 103, No. 8, pp. 2892-2899. Prepublished online as a Blood First Edition Paper on January 8, 2004; DOI 10.1182/blood-2003-08-2807. This Article Full Text (PDF) All Versions of this Article: 2003-08-2807v1 103/8/2892    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Prindull, G. Articles by Zipori, D. Search for Related Content PubMed PubMed Citation Articles by Prindull, G. Articles by Zipori, D. Social Bookmarking                   What's this? Submitted August 18, 2003 Accepted December 19, 2003 Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm Gregor Prindull and Dov Zipori* Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel * Corresponding author; email: dov.zipori{at}weizmann.ac.il. Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions of the microenvironment that stabilizes adult cell phenotypes and prevents plastic behaviour. Multipotential progenitor cells exhibiting a mesenchymal phenotype have been derived from various adult tissues. The ability of these cells to differentiate into all germ layer cell types, raises the question as to whether mesenchymal epithelial transitions occur in the adult organism more frequently than presently appreciated. A series of cytokines are known to promote the transitions between epithelium and mesenchyme. Moreover, several transcription factors and other intracellular regulator molecules have been conclusively shown to mediate these transitions. However, the exact molecular basis of these transitions is yet to be resolved. The identification of the restrictive mechanisms that prevent cellular transitions in adult organisms, that seem to be unleashed in cancerous tissues, may lead to the development of tools for therapeutic tissue repair and effective tumor suppression. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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