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Prepublished online as a Blood First Edition Paper on September 25, 2003; DOI 10.1182/blood-2003-08-2814. This Article Full Text (PDF) All Versions of this Article: 2003-08-2814v1 103/3/988    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schluns, K. S Articles by Lefrancois, L. Search for Related Content PubMed PubMed Citation Articles by Schluns, K. S Articles by Lefrancois, L. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted August 15, 2003 Accepted September 16, 2003 Trans-regulation of memory CD8 T-cell proliferation by IL-15R+ bone marrow-derived cells Kimberly S Schluns, Kimberly D Klonowski, and Leo Lefrancois* Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT, USA * Corresponding author; email: llefranc{at}neuron.uchc.edu. IL-15 and the IL-15R chain are both required for the basal proliferation of memory CD8 T cells, but which cell types are required to express IL-15 or IL-15R to mediate this proliferation is not known. Using bone marrow (BM) chimeras, we showed that virus-specific CD8 memory T cell proliferation was driven by IL-15 produced by either BM-derived or parenchymal cells. Experiments using mixed BM chimeras showed that IL-15R expression by memory CD8 T cells was not required for their division. In addition, wildtype memory CD8 T cells did not divide after transfer into IL-15R-/- mice. Further analyses demonstrated that IL-15R+ BM-derived cells were crucial in driving memory CD8 T cell division in the spleen while both parenchymal and BM-derived cells promoted memory cell division in the lung. Proliferation in response to soluble IL-15 in vivo required expression of IL-15R by opposing cells and IL-15R by CD8 memory cells, indicating that IL-15 interacted directly with the T cells. These results indicate that trans-presentation of IL-15 by IL-15R on BM-derived cells mediates the basal proliferation of memory CD8 T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Memory depending on an intimate relationship Yutaka Tagaya Blood 2004 103: 755-756. [Full Text] [PDF] This article has been cited by other articles: C. Bergamaschi, R. Jalah, V. Kulkarni, M. Rosati, G.-M. Zhang, C. Alicea, A. S. Zolotukhin, B. K. Felber, and G. N. 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