SEARCH:   Advanced

Blood, 15 June 2004, Vol. 103, No. 12, pp. 4674-4680. Prepublished online as a Blood First Edition Paper on January 15, 2004; DOI 10.1182/blood-2003-08-2815. This Article Full Text (PDF) All Versions of this Article: 2003-08-2815v1 103/12/4674    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by El-Zimaity, M. Articles by de Lima, M. Search for Related Content PubMed PubMed Citation Articles by El-Zimaity, M. Articles by de Lima, M. Social Bookmarking                   What's this? Submitted August 18, 2003 Accepted December 1, 2003 Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters Maha El-Zimaity, Rima Saliba, Kawah Chan, Munir Shahjahan, Antonio Carrasco, Ola Khorshid, Humberto Caldera, Daniel Couriel, Sergio Giralt, Issa Khouri, Cindy Ippoliti, Richard Champlin, and Marcos de Lima* Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX, USA * Corresponding author; email: mdelima{at}mdanderson.org. Hemorrhagic cystitis (HC) remains a common complication of allogeneic blood and marrow transplantation. Previous analyses of risk factors for this complication were performed in heterogenous populations, with dissimilar diagnosis and conditioning regimens. We postulated that HC is more prevalent in matched unrelated donor (MUD) and unrelated cord blood (UCB) transplants than in matched related donor (MRD) transplants. Retrospective study on 105 acute lymphocytic leukemia patients treated with 12 Gy total body irradiation based regimens and allogeneic transplants (MUD n=38; UCB, n=15; mismatched related, n=20 MRD, n=32). HC occurred in 16% of patients receiving MRD transplants, 30% of recipients of mismatched related, and 40% of MUD or UCB transplants (Hazard ratio 2.9, 95%CI 1.0-7.9 for the comparison of MRD versus MUD). The excessive rate of HC among MUD and UCB patients became evident after the first 30 days post transplant. Recipients younger than 26 years had a significantly higher incidence of HC (HR 2.5, 95%CI 1.1-5.8). This donor type and age effect was independent of platelet engraftment, development of GVHD, source of stem cells, use of ATG and cyclophosphamide in the regimen, steroid use, or stem cell source. We concluded that HC is more prevalent in MUD and UCB transplants. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D.-P. Lu, L. Dong, T. Wu, X.-J. Huang, M.-J. Zhang, W. Han, H. Chen, D.-H. Liu, Z.-Y. Gao, Y.-H. Chen, et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation Blood, April 15, 2006; 107(8): 3065 - 3073. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020