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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1373-1375. Prepublished online as a Blood First Edition Paper on October 23, 2003; DOI 10.1182/blood-2003-08-2859. This Article Full Text (PDF) All Versions of this Article: 2003-08-2859v1 103/4/1373    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yu, Y. Articles by Bischoff, J. Search for Related Content PubMed PubMed Citation Articles by Yu, Y. Articles by Bischoff, J. Social Bookmarking                   What's this? Submitted August 20, 2003 Accepted October 18, 2003 Endothelial Progenitor Cells in Infantile Hemangioma Ying Yu*, Alan F Flint, John B Mulliken, June K Wu, and Joyce Bischoff Program in Vascular Biology, Harvard Medical School, Boston, MA, USA; Children's Hospital, Harvard Medical School, Boston, MA, USA Division of Genetics, Harvard Medical School, Boston, MA, USA; Children's Hospital, Harvard Medical School, Boston, MA, USA Division of Plastic Surgery, Harvard Medical School, Boston, MA, USA; Children's Hospital, Harvard Medical School, Boston, MA, USA * Corresponding author; email: ying.yu{at}tch.harvard.edu. Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells co-expressing CD133 and CD34 were detected by flow cytometry in 11/12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14 - 1.6% of CD45negative nucleated cells were EPCs that co-expressed CD133 and the endothelial cell marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. L. Calicchio, T. Collins, and H. P. Kozakewich Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling Am. J. Pathol., May 1, 2009; 174(5): 1638 - 1649. [Abstract] [Full Text] [PDF] M. E. Kleinman, M. R. Greives, S. S. Churgin, K. M. Blechman, E. I. Chang, D. J. Ceradini, O. M. Tepper, and G. C. Gurtner Hypoxia-Induced Mediators of Stem/Progenitor Cell Trafficking Are Increased in Children With Hemangioma Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2664 - 2670. [Abstract] [Full Text] [PDF] N. Mehra, M. Penning, J. Maas, L. V. Beerepoot, N. van Daal, C. H. van Gils, R. H. Giles, and E. E. Voest Progenitor Marker CD133 mRNA Is Elevated in Peripheral Blood of Cancer Patients with Bone Metastases. Clin. Cancer Res., August 15, 2006; 12(16): 4859 - 4866. [Abstract] [Full Text] [PDF] Z. A. Khan, J. M. Melero-Martin, X. Wu, S. Paruchuri, E. Boscolo, J. B. Mulliken, and J. Bischoff Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin Blood, August 1, 2006; 108(3): 915 - 921. [Abstract] [Full Text] [PDF] M. R. Ritter, J. Reinisch, S. F. Friedlander, and M. Friedlander Myeloid Cells in Infantile Hemangioma Am. J. Pathol., February 1, 2006; 168(2): 621 - 628. [Abstract] [Full Text] [PDF] C. M. Barnes, S. Huang, A. Kaipainen, D. Sanoudou, E. J. Chen, G. S. Eichler, Y. Guo, Y. Yu, D. E. Ingber, J. B. Mulliken, et al. Evidence by molecular profiling for a placental origin of infantile hemangioma PNAS, December 27, 2005; 102(52): 19097 - 19102. [Abstract] [Full Text] [PDF] K. N. Smolinski and A. C. Yan Hemangiomas of Infancy: Clinical and Biological Characteristics Clinical Pediatrics, November 1, 2005; 44(9): 747 - 766. [Abstract] [PDF] T. L. Phung, M. Hochman, and M. C. Mihm Current Knowledge of the Pathogenesis of Infantile Hemangiomas Arch Facial Plast Surg, September 1, 2005; 7(5): 319 - 321. [Abstract] [Full Text] [PDF]

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