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Blood, 15 April 2004, Vol. 103, No. 8, pp. 3216-3221. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2003-08-2860. This Article Full Text (PDF) All Versions of this Article: 2003-08-2860v1 103/8/3216    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cozen, W. Articles by Mack, T. M Search for Related Content PubMed PubMed Citation Articles by Cozen, W. Articles by Mack, T. M Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted August 20, 2003 Accepted December 11, 2003 IL-6 Levels and Genotype are Associated with Risk of Young Adult Hodgkin Lymphoma Wendy Cozen*, Parkash S Gill, Sue A Ingles, Rizwan Masood, Otoniel Martinez-Maza, Myles G Cockburn, W J Gauderman, Malcolm C Pike, Leslie Bernstein, Bharat N Nathwani, Muhammad T Salam, Kathleen L Danley, Wei Wang, Julia Gage, Susan Gundell-Miller, and Thomas M Mack Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA * Corresponding author; email: wcozen{at}usc.edu. Identical twins of young adult Hodgkin lymphoma cases are much more likely to develop the disease compared to fraternal twins of cases, suggesting a genetic determinant. IL-6 levels are increased in Hodgkin lymphoma patients and are correlated with a poor prognosis. We hypothesized that a heritable abnormality in IL-6 regulation may predispose to young adult Hodgkin lymphoma. We obtained blood specimens from 88 young adult Hodgkin lymphoma cases and their twins, and from 87 matched controls. IL-6 was measured from unstimulated peripheral blood mononuclear cell (PBMC) supernatant with ELISA assays and compared using analysis of covariance. Unaffected identical twins of cases (surrogate cases) had a 68.6% higher IL-6 level compared to matched controls (mean difference = +304.6 pg/ml, p=0.04). Analysis of the IL-6 -174 G>C promoter polymorphism genotypes showed that risk decreased with an increasing number of C alleles (p= 0.01). The CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype (odds ratio, OR= 0.29; p= 0.03). Risk was decreased for nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Novel twin study implicates IL-6 in the etiology of young adult Hodgkin lymphoma James R. Cerhan Blood 2004 103: 2871-2872. [Full Text] [PDF] This article has been cited by other articles: W. Cozen, A. S. Hamilton, P. Zhao, M. T. Salam, D. M. Deapen, B. N. Nathwani, L. M. Weiss, and T. M. Mack A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma Blood, November 5, 2009; 114(19): 4014 - 4020. [Abstract] [Full Text] [PDF] R. J. Biggar, J. S. Johansen, K. E. Smedby, K. Rostgaard, E. T. 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