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Blood, 15 June 2004, Vol. 103, No. 12, pp. 4573-4580. Prepublished online as a Blood First Edition Paper on February 5, 2004; DOI 10.1182/blood-2003-08-2975. This Article Full Text (PDF) All Versions of this Article: 2003-08-2975v1 103/12/4573    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Samson, S. I Articles by Di Santo, J. P Search for Related Content PubMed PubMed Citation Articles by Samson, S. I Articles by Di Santo, J. P Social Bookmarking                   What's this? Submitted August 29, 2003 Accepted January 25, 2004 Combined deficiency in IB and IB reveals a critical window of NF-B activity in Natural Killer cell differentiation Sandrine I Samson, Sylvie Memet, Christian A Vosshenrich, Francesco Colucci, Odile Richard, Delphine Ndiaye, Alain Israel, and James P Di Santo* Immunology, Institut Pasteur, Paris, France Cell Biology, Institut Pasteur, Paris, France * Corresponding author; email: disanto{at}pasteur.fr. NF-B/Rel transcription factors are key regulators of immune, inflammatory and acute phase responses and are also implicated in the control of cell proliferation and apoptosis. While perturbations in NF-B activity impact strongly on B and T cell development, little is known about the role for NF-B in NK cell differentiation. Inhibitors of NF-B (IB) act to restrain NF-B activation. We analyzed the cell-intrinsic effects of deficiencies in two IB members (IB and IB) on NK cell differentiation. Neither IB- nor IB-deficiency had major effects on NK cell generation, while their combined absence led to NF-B hyper-activation, resulting in reduced NK cell numbers, incomplete NK cell maturation and defective IFN- production. Complementary analysis of transgenic mice expressing a NF-B-responsive reporter gene showed increased NF-B activity at the stage of NK cell development corresponding to the partial block observed in IB x I deficient mice. These results define a critical window in NK cell development in which NF-B levels may be tightly controlled. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Penafuerte, N. Bautista-Lopez, B. Mohamed-Rachid, J.-P. Routy, and J. Galipeau The Human Ortholog of Granulocyte Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion Protein Induces Potent Ex vivo Natural Killer Cell Activation and Maturation Cancer Res., December 1, 2009; 69(23): 9020 - 9028. [Abstract] [Full Text] [PDF] R. Pandey, C. M. DeStephan, L. A. Madge, M. J. May, and J. S. Orange NKp30 Ligation Induces Rapid Activation of the Canonical NF-{kappa}B Pathway in NK Cells J. Immunol., December 1, 2007; 179(11): 7385 - 7396. [Abstract] [Full Text] [PDF] V. Pascal, N. R. Nathan, E. Claudio, U. Siebenlist, and S. K. Anderson NF-{kappa}B p50/p65 Affects the Frequency of Ly49 Gene Expression by NK Cells J. Immunol., August 1, 2007; 179(3): 1751 - 1759. [Abstract] [Full Text] [PDF] J. M. P. Schmid, S. A. Junge, J. P. Hossle, E. M. Schneider, E. Roosnek, R. A. Seger, and T. Gungor Transient Hemophagocytosis With Deficient Cellular Cytotoxicity, Monoclonal Immunoglobulin M Gammopathy, Increased T-Cell Numbers, and Hypomorphic NEMO Mutation Pediatrics, May 1, 2006; 117(5): e1049 - e1056. [Abstract] [Full Text] [PDF] W. Huang, H. D. Ochs, B. Dupont, and Y. M. Vyas The Wiskott-Aldrich Syndrome Protein Regulates Nuclear Translocation of NFAT2 and NF-{kappa}B (RelA) Independently of Its Role in Filamentous Actin Polymerization and Actin Cytoskeletal Rearrangement J. Immunol., March 1, 2005; 174(5): 2602 - 2611. [Abstract] [Full Text] [PDF] C. A. J. Vosshenrich, T. Ranson, S. I. Samson, E. Corcuff, F. Colucci, E. E. Rosmaraki, and J. P. Di Santo Roles for Common Cytokine Receptor {gamma}-Chain-Dependent Cytokines in the Generation, Differentiation, and Maturation of NK Cell Precursors and Peripheral NK Cells in Vivo J. Immunol., February 1, 2005; 174(3): 1213 - 1221. [Abstract] [Full Text] [PDF]

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