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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1534-1541. Prepublished online as a Blood First Edition Paper on October 9, 2003; DOI 10.1182/blood-2003-08-2987. This Article Full Text (PDF) All Versions of this Article: 2003-08-2987v1 103/4/1534    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, B. J Articles by Chao, N. J Search for Related Content PubMed PubMed Citation Articles by Chen, B. J Articles by Chao, N. J Social Bookmarking                   What's this? Submitted September 2, 2003 Accepted October 1, 2003 Transfer of allogeneic CD62L- memory T cells without graft-vs.-host disease Benny J Chen, Xiuyu Cui, Gregory D Sempowski, Congxiao Liu, and Nelson J Chao* Bone Marrow Transplantation Program, Duke University Medical Center, Durham, NC, USA Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA * Corresponding author; email: chao0002{at}mc.duke.edu. The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T cell immunity without causing graft-vs.-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and a subset of memory T cells). In unprimed mice, CD62L- T cells (a subset of memory T cells) failed to proliferate upon response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic host. CD62L- T cells contributed to T cell reconstitution by peripheral expansion as well as by promoting T cell regeneration from bone marrow stem/progenitor cells. CD62L- T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo, but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall anti-tumor and anti-microbial immunity without causing GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Bohana-Kashtan, S. Morisot, R. Hildreth, C. Brayton, H. I. Levitsky, and C. I. Civin Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand J. Immunol., July 1, 2009; 183(1): 696 - 705. [Abstract] [Full Text] [PDF] H. Zheng, C. Matte-Martone, D. Jain, J. McNiff, and W. D. 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