Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 March 2004, Vol. 103, No. 6, pp. 2391-2396.
Prepublished online as a Blood First Edition Paper on November 13, 2003; DOI 10.1182/blood-2003-09-3015.

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2003-09-3015v1
103/6/2391    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoppe, C.
Right arrow Articles by Styles, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoppe, C.
Right arrow Articles by Styles, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted September 3, 2003
Accepted October 31, 2003

Gene interactions and stroke risk in children with sickle cell anemia

Carolyn Hoppe*, William Klitz, Suzanne Cheng, Ray Apple, Lori Steiner, Lara Robles, Tom Girard, Elliott Vichinsky, and Lori Styles

Department of Hematology/Oncology, Children's Hospital & Research Center at Oakland, Oakland, CA, USA
Department of Human Genetics, Roche Molecular Systems Inc., Alameda, CA, USA

* Corresponding author; email: choppe{at}mail.cho.org.

Stroke is a devastating complication of sickle cell anemia (SCA), affecting up to 30% children. Despite the relative frequency of stroke in SCA, few predictors of risk exist. Because stroke in SCA is likely a multifactorial disease, analysis of the combined effect of multiple genetic variants may prove more successful than evaluation of individual candidate genes. We genotyped 230 children with SCA for 104 polymorphisms among 65 candidate vascular genes to identify risk associations with stroke. Patients were phenotyped based on magnetic resonance imaging/angiography (MRI/MRA) findings into large (LV) vs. small vessel (SV) disease stroke subgroups. Specific polymorphisms in the IL4R 503, TNF (-308), and ADRB2 27 genes were independently associated with stroke susceptibility in the LV stroke subgroup, while variants in the VCAM1 (-1594) and LDLR NcoI genes were associated with SV stroke risk. The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (OR = 5.5, 95% CI = 2.3-13.1). We show that several candidate genes may play a role in predisposition to specific stroke subtypes in children with SCA. If confirmed, these results provide a basis for population screening and targeted intervention to prevent stroke in SCA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 StrokeHome page
C. Lee and M. Kong
An Interactive Association of Common Sequence Variants in the Neuropeptide Y Gene With Susceptibility to Ischemic Stroke
Stroke, October 1, 2007; 38(10): 2663 - 2669.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. Hoppe, W. Klitz, K. D'Harlingue, S. Cheng, M. Grow, L. Steiner, J. Noble, R. Adams, L. Styles, and for the Stroke Prevention Trial in Sickle Cell Ane
Confirmation of an Association Between the TNF( 308) Promoter Polymorphism and Stroke Risk in Children With Sickle Cell Anemia
Stroke, August 1, 2007; 38(8): 2241 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. M. Iovannisci, E. J. Lammer, L. Steiner, S. Cheng, L. T. Mahoney, P. H. Davis, R. M. Lauer, and T. L. Burns
Association Between A Leukotriene C4 Synthase Gene Promoter Polymorphism and Coronary Artery Calcium in Young Women: The Muscatine Study
Arterioscler. Thromb. Vasc. Biol., February 1, 2007; 27(2): 394 - 399.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. J. Wu, L. Krishnamurti, J. L. Kutok, M. Biernacki, S. Rogers, W. Zhang, J. H. Antin, and J. Ritz
Evidence for ineffective erythropoiesis in severe sickle cell disease
Blood, November 15, 2005; 106(10): 3639 - 3645.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Lan, L. Zhang, M. Shen, M. T. Smith, G. Li, R. Vermeulen, S. M. Rappaport, M. S. Forrest, R. B. Hayes, M. Linet, et al.
Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene
Cancer Res., October 15, 2005; 65(20): 9574 - 9581.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
X. Guo, S. Cheng, K. D. Taylor, J. Cui, R. Hughes, M. J. Quinones, I. Bulnes-Enriquez, R. De La Rosa, G. Aurea, H. Yang, et al.
Hypertension Genes Are Genetic Markers for Insulin Sensitivity and Resistance
Hypertension, April 1, 2005; 45(4): 799 - 803.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. M. Ferriero
Neonatal Brain Injury
N. Engl. J. Med., November 4, 2004; 351(19): 1985 - 1995.
[Full Text] [PDF]

Home page
 ASH Education BookHome page
G. R. Buchanan, M. R. DeBaun, C. T. Quinn, and M. H. Steinberg
Sickle Cell Disease
Hematology, January 1, 2004; 2004(1): 35 - 47.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020