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Blood, 15 April 2004, Vol. 103, No. 8, pp. 2990-2996. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2003-09-3030. This Article Full Text (PDF) All Versions of this Article: 2003-09-3030v1 103/8/2990    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Perry, S S Articles by Spangrude, G. J Search for Related Content PubMed PubMed Citation Articles by Perry, S S Articles by Spangrude, G. J Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted September 3, 2003 Accepted December 19, 2003 L-Selectin Defines a Bone Marrow Analogue to the Thymic Early T-Lineage Progenitor S S Perry, Hongfang Wang, L J Pierce, Anne Marie Yang, Schickwann Tsai, and Gerald J Spangrude* Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA Department of Pathology, University of Utah, Salt Lake City, UT, USA Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, UT, USA * Corresponding author; email: gspangrude{at}mac.com. The recent description of an early T-lineage progenitor (ETP) population in adult mouse thymus implies the presence of a bone marrow predecessor that has not yet been identified. Here we describe a LinNeg Sca-1Pos c-kitHi Thy-1.1Neg L-selectinPos adult mouse bone marrow population that resembles the thymic ETP in both antigen expression phenotype and post-transplant lineage potential. These cells produce wave-like kinetics of thymic seeding, and reconstitute the irradiated thymus with kinetics comparable to a thymocyte graft after IV transplant. Transient B lineage reconstitution is also observed, but little myeloid potential can be detected in transplant experiments. A second subset of progenitors is L-selectinNeg and is highly enriched for rapid and persistent T and B lineage potential, as well as some myeloid potential. L-selectin (CD62L) is therefore an effective marker for separating lymphoid progenitors from myeloid progenitors and HSC in mouse bone marrow. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Bridging the bone marrow–thymus gap Markus G. Manz Blood 2004 103: 2869. [Full Text] [PDF] This article has been cited by other articles: C. Weber, A. Krueger, A. Munk, C. Bode, P. P. Van Veldhoven, and M. H. 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