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 Blood, 1 April 2004, Vol. 103, No. 7, pp. 2474-2479.
Prepublished online as a Blood First Edition Paper on November 26, 2003; DOI 10.1182/blood-2003-09-3080.

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Submitted September 8, 2003
Accepted November 13, 2003

Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study

Andrea Gallamini*, Caterina Stelitano, Roberta Calvi, Monica Bellei, Daniele Mattei, Umberto Vitolo, Fortunato Morabito, Maurizio Martelli, Ercole Brusamolino, Emilio Iannitto, Francesco Zaja, Sergio Cortelazzo, Luigi Rigacci, Liliana Devizzi, Giuseppe Todeschini, Gino Santini, Maura Brugiatelli, and Massimo Federico

Division of Hematology, Azienda Ospedaliera S.Croce e Carle, Cuneo, Italy
Division of Hematology, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy
Department of Medical Oncology, Modena and Reggio Emillia University, Modena, Italy
Division of Hematology, Azienda Ospedaliera S. Giovanni Battista, Turin, Italy
BMT Unit, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy
Division of Hematology, IRCCS Policlinico S. Matteo, Pavia, Italy
Onco-Hematology and BMT Unit, Palermo University, Palermo, Italy
Department of Cellular Biotechnology and Hematology, La Sapienza University, Rome, Italy
Department of Medical Research and Morphology, Policlinico Universitario, Udine, Italy
Division of Hematology, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy
Division of Hematology, Policlinico Careggi, Florence, Italy
Department of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy
Division of Hematology, Verona University, Verona, Italy
Division of Hematology, Azienda Ospedaliera Ospedale S. Martino, Genova, Italy
Division of Hematology, Azienda Ospedaliera Papardo, Messina, Italy

* Corresponding author; email: gallamini.a{at}scroce.sanitacn.it.

In order to assess the prognosis of Peripheral T-Cell Lymphoma-Unspecified, we retrospectively analyzed 385 cases fulfilling the criteria defined by the WHO classification. Factors associated with a worst overall survival (OS) in a univariate analysis were: age > 60 (p=0.0002), >= 2 ENS (p= 0.0002), LDH >= normal levels (p<0.0001), PS >= 2 (p<0.0001), stage >= III (p=0.0001), bone marrow involvement (p=0.0001). Multivariate analysis showed that age (relative risk 1.732, 95% C.I. 1.300-2.309, p< 0.0001), PS (relative risk 1.719, 95% C.I. 1.269-2.327, p< 0.0001), LDH (relative risk 1.905, 95% C.I. 1.415-2.564, p< 0.0001) and bone marrow involvement (relative risk 1.454, 95% C.I. 1.045-2.023, p=0.026) were factors independently predictive for survival. Using these four variables we constructed a new prognostic model which singled out 4 groups at different risk; group 1: no adverse factors, with 5-year and 10-year OS of 62.3% and 54.9%, respectively; group 2: 1 factor, with a 5-year and 10-year OS of 52.9% and 38.8%, respectively; group 3: 2 factors, with 5-year and 10-year OS of 32.9% and 18.0%, respectively; group 4: 3 or 4 factors, with a 5-year and 10-year OS of 18.3 and 12.6%, respectively (p= 0.0000, log rank 66.79).


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