|
|
Blood, 15 July 2004, Vol. 104, No. 2, pp. 502-508.
Prepublished online as a Blood First Edition Paper on March 4, 2004; DOI 10.1182/blood-2003-09-3103.
Submitted September 15, 2003
Accepted February 25, 2004
Homeostatic Chemokines Drive Migration of Malignant B cells in Patients with Non-Hodgkin's Lymphomas
Livio Trentin, Anna Cabrelle, Monica Facco, Davide Carollo, Marta Miorin, Alicia Tosoni, Paola Pizzo, Gianni Binotto, Linda Nicolardi, Renato Zambello, Fausto Adami, Carlo Agostini, and Gianpietro Semenzato*
Dept. of Clinical and Experimental Medicine, University of Padova, Padova, Italy; Venetian Institute for Molecular Medicine, Padova, Italy
Dept. of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Department of Experimental Biomedical Sciences, University of Padova, Padova, Italy
* Corresponding author; email: g.semenzato{at}unipd.it.
This study was aimed to investigate the role of several chemokine and their receptors on malignant B lymphocytes recovered from patients with chronic lymphocytic leukemia (CLL, 13 patients), hairy cell leukemia (HCL, 9 patients), mantle cell lymphoma (MCL, 5 patients), marginal zone B cell lymphoma (MZL, 5 patients), lymphocytic lymphoma (SLL, 6 patients) and follicular cell lymphoma (FCL, 5 patients). Flow cytometry analysis demonstrated that CXCR4 and CXCR5 were expressed on all malignant and normal B cells. Considering CC receptors, CCR1 was expressed in 70% of CLL and 40% of HCL patients but lacking in MCL, MZL, SLL and normal B cells. CCR2 showed a heterogenous pattern of expression. CCR3 was found in almost all patients with CLL and in the majority of HCL subjects, while it was usually lacking in MZL, SLL and healthy subjects. CCR5 was expressed in HCL and MCL. Migration assays showed that different chemokines, mainly CXCL12 and CXCL13, are able to trigger migration of malignant B lymphocytes. Some of these chemokines induce calcium mobilization. These data indicate that different patterns of chemokine receptor expression identify different malignant B cell subsets and that these receptors are functional and might play a role in malignant B-cell circulation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. A. Burger, P. Ghia, A. Rosenwald, and F. Caligaris-Cappio
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
Blood,
October 15, 2009;
114(16):
3367 - 3375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Fischer, A. Korfel, S. Pfeiffer, P. Kiewe, H.-D. Volk, H. Cakiroglu, T. Widmann, and E. Thiel
CXCL13 and CXCL12 in Central Nervous System Lymphoma Patients
Clin. Cancer Res.,
October 1, 2009;
15(19):
5968 - 5973.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. V. Kurtova, A. T. Tamayo, R. J. Ford, and J. A. Burger
Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting
Blood,
May 7, 2009;
113(19):
4604 - 4613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Nielander, J. I. Martin-Subero, F. Wagner, M. Baudis, S. Gesk, L. Harder, D. Hasenclever, W. Klapper, M. Kreuz, C. Pott, et al.
Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma
Haematologica,
June 1, 2008;
93(6):
949 - 950.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. T. Pals, D. J. J. de Gorter, and M. Spaargaren
Lymphoma dissemination: the other face of lymphocyte homing
Blood,
November 1, 2007;
110(9):
3102 - 3111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ocana, L. Delgado-Perez, A. Campos-Caro, J. Munoz, A. Paz, R. Franco, and J. A. Brieva
The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells
Haematologica,
March 1, 2007;
92(3):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ame-Thomas, H. Maby-El Hajjami, C. Monvoisin, R. Jean, D. Monnier, S. Caulet-Maugendre, T. Guillaudeux, T. Lamy, T. Fest, and K. Tarte
Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis
Blood,
January 15, 2007;
109(2):
693 - 702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Meijer, I. S. Zeelenberg, B. Sipos, and E. Roos
The CXCR5 Chemokine Receptor Is Expressed by Carcinoma Cells and Promotes Growth of Colon Carcinoma in the Liver
Cancer Res.,
October 1, 2006;
66(19):
9576 - 9582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Holland, M. Kochetkova, C. Akekawatchai, M. Dottore, A. Lopez, and S. R. McColl
Differential functional activation of chemokine receptor CXCR4 is mediated by g proteins in breast cancer cells.
Cancer Res.,
April 15, 2006;
66(8):
4117 - 4124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Burger and T. J. Kipps
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Blood,
March 1, 2006;
107(5):
1761 - 1767.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Akekawatchai, J. D. Holland, M. Kochetkova, J. C. Wallace, and S. R. McColl
Transactivation of CXCR4 by the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Human MDA-MB-231 Breast Cancer Epithelial Cells
J. Biol. Chem.,
December 2, 2005;
280(48):
39701 - 39708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Jahnke, S. E. Coupland, I.-K. Na, C. Loddenkemper, U. Keilholz, A. Korfel, H. Stein, E. Thiel, and C. Scheibenbogen
Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma
Blood,
July 1, 2005;
106(1):
384 - 385.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Piovan, V. Tosello, S. Indraccolo, A. Cabrelle, I. Baesso, L. Trentin, R. Zamarchi, H. Tamamura, N. Fujii, G. Semenzato, et al.
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation
Blood,
February 1, 2005;
105(3):
931 - 939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
