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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2691-2698. Prepublished online as a Blood First Edition Paper on November 26, 2003; DOI 10.1182/blood-2003-09-3184. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2003-09-3184v1 103/7/2691    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rosenblum, M. D Articles by Truitt, R. L Search for Related Content PubMed PubMed Citation Articles by Rosenblum, M. D Articles by Truitt, R. L Social Bookmarking                   What's this? Submitted September 22, 2003 Accepted November 20, 2003 CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance Michael D Rosenblum, Edit Olasz, Jeffrey E Woodliff, Bryon D Johnson, Marja C Konkol, Kimberly A Gerber, Rimas J Orentas, Gordon Sandford, and Robert L Truitt* Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA Oncology-Cancer Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA * Corresponding author; email: rtruitt{at}mcw.edu. During apoptotic cell death, biochemical processes modify self-proteins and create potential autoantigens. To maintain self-tolerance in the face of natural cell turnover, the immune system must prevent or control responses to apoptosis-associated autoantigens or risk autoimmuity. The molecular mechanisms governing this process remain largely unknown. Here we show that expression of the immunoregulatory protein CD200 increases as murine dendritic cells (DCs) undergo apoptosis. We define CD200 as a p53-target gene and identify both p53- and caspase-dependent pathways that control CD200 expression during apoptosis. CD200 expression on apoptotic DCs diminishes pro-inflammatory cytokine production in response to self-antigens in vitro and is required for UVB-mediated tolerance to haptenated self-proteins in vivo. Up-regulation of CD200 may represent a novel mechanism whereby immune reactivity to apoptosis-associated self-antigens is suppressed under steady state conditions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. M. Gorczynski, Z. Chen, W. He, I. Khatri, Y. Sun, K. Yu, and I. Boudakov Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts J. Immunol., August 1, 2009; 183(3): 1560 - 1568. [Abstract] [Full Text] [PDF] R. Gorczynski, I. Khatri, L. Lee, and I. Boudakov An Interaction between CD200 and Monoclonal Antibody Agonists to CD200R2 in Development of Dendritic Cells That Preferentially Induce Populations of CD4+CD25+ T Regulatory Cells J. Immunol., May 1, 2008; 180(9): 5946 - 5955. [Abstract] [Full Text] [PDF]

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