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Blood, 15 May 2004, Vol. 103, No. 10, pp. 3986-3988. Prepublished online as a Blood First Edition Paper on February 5, 2004; DOI 10.1182/blood-2003-09-3286. This Article Full Text (PDF) All Versions of this Article: 2003-09-3286v1 103/10/3986    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yamashita, K. Articles by Horwitz, M. E Search for Related Content PubMed PubMed Citation Articles by Yamashita, K. Articles by Horwitz, M. E Social Bookmarking                   What's this? Submitted September 25, 2003 Accepted January 22, 2004 Severe Chronic Graft-Versus-Host Disease is Characterized by a Preponderance of CD4+ Effector Memory Cells Relative to Central Memory Cells Kouhei Yamashita*, Uimook Choi, Patricia C Woltz, Susan F Foster, Michael C Sneller, Francis T Hakim, Daniel H Fowler, Michael R Bishop, Steven Z Pavletic, Marisa Tamari, Kathleen Castro, A J Barrett, Richard W Childs, Gabor G Illei, Susan F Leitman, Harry L Malech, and Mitchell E Horwitz Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA Experimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA Hematology Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD, USA Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA; Bone Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA * Corresponding author; email: kyamashita{at}niaid.nih.gov. Donor alloreactive CD4+ T-cells are important to the pathogenesis of chronic graft-versus-host disease (cGvHD), but specific subsets of CD4 T-cells responsible for GvHD have not been identified. We hypothesized that cGvHD might be associated with a preponderance of CD4+ effector memory cells (CCR7-/CD62Llow, CD4EM). We analyzed CCR7 and CD62L expression on CD4+ T-cells from stem cell transplant patients with or without cGvHD, and healthy donors. Patients with cGvHD had a higher percentage of CD4EM cells (35.5±2.9%) than healthy donors (13.8±0.7%, p<0.0001) or transplanted patients without cGvHD (21.7±2.1%, p<0.01). Using corticosteroid dose as a surrogate marker for cGvHD severity, severe cGvHD was associated with a higher percentage of CD4EM cells. The proportion of CD4EM cells in corticosteroid-dependent patients with systemic lupus erythematosis or Wegener's granulomatosis did not differ from transplanted patients without cGvHD. This finding implies that overrepresentation of CD4EM cells is a unique feature of cGvHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Patel, K. E. Kirkland, R. Szydlo, R. M. Pearce, R. E. Clark, C. Craddock, E. Liakopoulou, A. K. Fielding, S. Mackinnon, E. Olavarria, et al. Favorable outcomes with alemtuzumab-conditioned unrelated donor stem cell transplantation in adults with high-risk Philadelphia chromosome-negative acute lymphoblastic leukemia in first complete remission Haematologica, October 1, 2009; 94(10): 1399 - 1406. [Abstract] [Full Text] [PDF] K. Matthews, Z. Lim, B. Afzali, L. Pearce, A. Abdallah, S. Kordasti, A. Pagliuca, G. Lombardi, J. A. Madrigal, G. J. Mufti, et al. 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