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Blood, 15 April 2004, Vol. 103, No. 8, pp. 3102-3110. Prepublished online as a Blood First Edition Paper on December 24, 2003; DOI 10.1182/blood-2003-09-3311. This Article Full Text (PDF) All Versions of this Article: 2003-09-3311v1 103/8/3102    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blais, M.-E. Articles by Perreault, C. Search for Related Content PubMed PubMed Citation Articles by Blais, M.-E. Articles by Perreault, C. Social Bookmarking                   What's this? Submitted September 26, 2003 Accepted December 10, 2003 Do thymically and strictly extrathymically developing T cells generate similar immune responses? Marie-Eve Blais, Gwladys Gerard, Marianne M Martinic, Guillaume Roy-Proulx, Rolf M Zinkernagel, and Claude Perreault* Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital, Montreal, PQ, Canada Institute for Experimental Immunology, University Hospital, Zurich, Switzerland * Corresponding author; email: c.perreault{at}videotron.ca. If present in sufficient numbers, could extrathymic T cells substitute for thymus-derived T cells? To address this issue, we studied extrathymic T cells that develop in athymic mice under the influence of oncostatin M (OM). In this model, extensive T cell development is probably due to amplification of a minor pathway of T cell differentiation taking place only in the lymph nodes. Extrathymic CD4 T cells expanded poorly and were deficient in providing B cell help after infection with vesicular stomatitis virus (VSV) and lymphocytic choriomeningitis virus (LCMV). Compared with classic T cells, stimulated extrathymic CD8 T cells produced copious amounts of IFN-, and their expansion was precocious but of limited amplitude because of a high apoptosis rate. Consequently, although extrathymic CTLs responded to LCMV infection, as evidenced by the expansion of GP33-41 tetramer+ CD8 T cells, they were unable to eradicate the virus. Our data indicate that the site of development impinges on T cell quality and function and that extrathymic T cells functionally cannot substitute for classical thymic T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M.-E. Blais, S. Brochu, M. Giroux, M.-P. Belanger, G. Dulude, R.-P. Sekaly, and C. Perreault Why T Cells of Thymic Versus Extrathymic Origin Are Functionally Different J. Immunol., February 15, 2008; 180(4): 2299 - 2312. [Abstract] [Full Text] [PDF] V. H. Nguyen, S. Shashidhar, D. S. Chang, L. Ho, N. Kambham, M. Bachmann, J. M. Brown, and R. S. Negrin The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation Blood, January 15, 2008; 111(2): 945 - 953. [Abstract] [Full Text] [PDF] M. S. Ford, Z.-X. Zhang, W. Chen, and L. Zhang Double-Negative T Regulatory Cells Can Develop Outside the Thymus and Do Not Mature from CD8+ T Cell Precursors. J. Immunol., September 1, 2006; 177(5): 2803 - 2809. [Abstract] [Full Text] [PDF] R. Terra, I. Louis, R. Le Blanc, S. Ouellet, J. C. Zuniga-Pflucker, and C. Perreault T-cell generation by lymph node resident progenitor cells Blood, July 1, 2005; 106(1): 193 - 200. [Abstract] [Full Text] [PDF]

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