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Blood, 1 June 2004, Vol. 103, No. 11, pp. 4330-4335. Prepublished online as a Blood First Edition Paper on February 12, 2004; DOI 10.1182/blood-2003-09-3325. This Article Full Text (PDF) All Versions of this Article: 2003-09-3325v1 103/11/4330    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Reddy, V. Articles by Wingard, J. R Search for Related Content PubMed PubMed Citation Articles by Reddy, V. Articles by Wingard, J. R Social Bookmarking                   What's this? Submitted September 29, 2003 Accepted January 30, 2004 Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease Vijay Reddy*, Jose A Iturraspe, Alessandra C Tzolas, Herwig-Ulf Meier-Kriesche, Jesse Schold, and John R Wingard College of Medicine, University of Florida, Gainesville, FL, USA Flow Cytometry, Lifesouth Community Blood Centers, Gainesville, FL, USA * Corresponding author; email: reddyvs{at}medicine.ufl.edu. Dendritic cells (DC) are key antigen presenting cells, with a potential role in tumor vaccines. We investigated the hypothesis that early reconstitution of DC after allogeneic hematopoietic stem cell transplantation (SCT) improves survival. We also correlated DC reconstitution with complications of relapse and acute graft-versus-host disease (AGVHD). Fifty patients were transplanted between February 2000 and March 2003 with a median follow up of 501 days (range 136-1263). Most received blood stem cells (92%), and the remainder, bone marrow from HLA matched sibling donors for predominantly high risk hematologic malignancies. Around the time of engraftment, peripheral blood was analyzed by flow cytometry for DC, and further divided as DC1 and DC2. Patients with lower DC count (<4.97 cells/mm3) had a significantly worse survival by Kaplan-Meier analysis (p=0.002), increased incidence of relapse (p=0.002), a higher incidence of AGVHD onset (p=0.0005) and a composite end point of relapse or death (p=0.0017). A Cox-proportional Hazard multivariate model adjusted for important covariates confirmed that low DC count is independently associated with death (HR 3.8; p=0.02), time to relapse (HR 11.6; p=0.001) and AGVHD (HR=3.3; p=0.04). The sensitivity and specificity of low DC count in predicting death or relapse is 73% and 75% respectively. Low number of circulating DC significantly increases risk for relapse and acute GVHD and predicts death after allogeneic SCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. M. Dunbar, M. P. Buzzeo, J. B. Levine, J. D. Schold, H.-U. Meier-Kriesche, and V. Reddy The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease Haematologica, December 1, 2008; 93(12): 1852 - 1858. [Abstract] [Full Text] [PDF] C. Talarn, A. Urbano-Ispizua, R. Martino, J. A. Perez-Simon, M. Batlle, C. Herrera, M. Granell, A. Gaya, M. Torrebadell, F. Fernandez-Aviles, et al. Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome Haematologica, December 1, 2007; 92(12): 1655 - 1663. [Abstract] [Full Text] [PDF] P. Athanassopoulos, L. M.B. Vaessen, A. H.M.M. Balk, J. J.M. Takkenberg, A. P.W.M. Maat, W. Weimar, and A. J.J.C. Bogers Impaired circulating dendritic cell reconstitution identifies rejecting recipients after clinical heart transplantation independent of rejection therapy Eur. J. Cardiothorac. Surg., May 1, 2005; 27(5): 783 - 789. [Abstract] [Full Text] [PDF] V. Reddy, A. G. Winer, E. Eksioglu, J. Levine, H.-U. Meier-Kriesche, J. Schold, H. Mossak, and J. R. Wingard High Levels of Interleukin-12 Are Associated with Reduced Incidence of Relapse and Death without Increasing Acute Graft-Versus-Host Disease (AGVHD) after Allogeneic Stem Cell Transplantation (SCT). Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 295 - 295. [Abstract] [Full Text]

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