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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1796-1798.
Prepublished online as a Blood First Edition Paper on October 30, 2003; DOI 10.1182/blood-2003-10-3372.
Submitted October 3, 2003
Accepted October 27, 2003
Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer cell inhibitory ligand, ILT2
Mirjana Urosevic*, Jivko Kamarashev, Guenter Burg, and Reinhard Dummer
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
* Corresponding author; email: Mirjana.Urosevic{at}usz.ch.
Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas are rare entities that have only been recently recognized and characterized. These lymphomas often show aggressive clinical course. We investigated the expression of HLA-G, IL-10 in conjunction with expression of HLA-G killer cell inhibitory receptor ligand ILT2 in 3 CD56+/CD4+ and 4 CD8+ cutaneous T-cell lymphomas. HLA-G expression was detected in 2 out of 3 lymphomas of CD56+/CD4+ type and in all lymphomas of CD8+ type. It is of note that CD56+/CD4+ lymphomas displayed stronger HLA-G reactivity. The expression of IL-10 matched the expression of HLA-G. Together with the expression of IL-10, HLA-G might be one of the factors accounting for the evasion of immunosurveillance thus contributing to aggressive phenotype of these lymphoma entities.
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