SEARCH:   Advanced

Blood, 15 August 2004, Vol. 104, No. 4, pp. 1210-1216. Prepublished online as a Blood First Edition Paper on April 22, 2004April 15, 2004; DOI 10.1182/blood-2003-10-3387. This Article Full Text (PDF) All Versions of this Article: 2003-10-3387v1 2003-10-3387v2 104/4/1210    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stelljes, M. Articles by Kienast, J. Search for Related Content PubMed PubMed Citation Articles by Stelljes, M. Articles by Kienast, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 3, 2003 Accepted April 2, 2004 Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets Mattihas Stelljes, Robert Strothotte, Hans-Gerd Pauels, Christopher Poremba, Michaela Milse, Christiane Specht, Jorn Albring, Guido Bisping, Christian Scheffold, Thomas Kammertoens, Elisabeth Oelmann, Gerda Silling, Wolfgang E Berdel, and Joachim Kienast* Department of Medicine / Hematology and Oncology, University of Muenster, Muenster, Germany Department of Immunology, University of Muenster, Muenster, Germany Department of Pathology, University of Duesseldorf, Duesseldorf, Germany School of Veterinary Medicine, Hannover, Germany Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany * Corresponding author; email: kienast{at}uni-muenster.de. Cure of hematological malignancies after allogeneic hematopoietic stem cell transplantation is partially attributable to immunocellular anti-tumor reactions termed graft-versus-tumor (GvT) effect. GvT effects are heterogeneous with respect to effector cell populations, target antigens and their interrelation with graft-versus-host disease (GvHD). In the present study allogeneic parent-into-F1 murine transplant models (BALB/c or C57BL/6 -> F1[BALB/c x C57BL/6]) with different tumors derived from either parental strain were used to evaluate tumor-specific GvT effects. Compared with syngeneic F1-into-F1 controls, significant CD8+ T cell-mediated GvT effects occurred in both allogeneic transplant models, even in the absence of histoincompatibilities between donor cells and host tumor. Identical genetic background of donor and tumor precluded allorecognition of tumor cells indicating that tumor-associated antigens (TAAs) were targeted. Allowing for selective MHC disparities between donor cells and normal host tissue, GvHD was identified as a driving force for TAA-specific GvT effects. Adoptive transfer of the effector cells into secondary tumor-bearing recipients confirmed sustained anti-tumor activity and specificity of the T cell response. The results provide experimental proof of a donor CD8+ T cell-mediated TAA-specific anti-tumor response in vivo that is driven by GvHD. It may represent one of the mechanisms contributing to GvT effects observed in allogeneic transplant recipients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Stelljes, S. Hermann, J. Albring, G. Kohler, M. Loffler, C. Franzius, C. Poremba, V. Schlosser, S. Volkmann, C. Opitz, et al. Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography Blood, March 1, 2008; 111(5): 2909 - 2918. [Abstract] [Full Text] [PDF] F. Carnevale-Schianca, A. Cignetti, A. Capaldi, K. Vitaggio, A. Vallario, A. Ricchiardi, E. Sperti, R. Ferraris, M. Gatti, G. Grignani, et al. Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD Blood, May 1, 2006; 107(9): 3795 - 3803. [Abstract] [Full Text] [PDF] M. Ohashi, A. Kobayashi, H. Hara, Y. Miura, K. Yoshida, M. Kushida, Y. Ikarashi, M. Mandai, M. Kitajima, T. Yoshida, et al. Allogeneic MHC gene transfer enhances antitumor activity of allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease. Clin. Cancer Res., April 1, 2006; 12(7 Pt 1): 2208 - 2215. [Abstract] [Full Text] [PDF] M. T. Kuhlmann, P. Kirchhof, R. Klocke, L. Hasib, J. Stypmann, L. Fabritz, M. Stelljes, W. Tian, M. Zwiener, M. Mueller, et al. G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis J. Exp. Med., January 23, 2006; 203(1): 87 - 97. [Abstract] [Full Text] [PDF] J. C. Albring, M. Stelljes, W. E. Berdel, and J. Kienast Graft-Versus-Tumor (GvT) Effects in the Absence of Alloantigens on Tumor Cells Crucially Depend on Graft-Versus-Host Disease (GvHD) Intensity. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 1304 - 1304. [Abstract] M. Kami, A. Makimoto, Y. Heike, and Y. Takaue Reduced-intensity Hematopoietic Stem Cell Transplantation (RIST) for Solid Malignancies Jpn. J. Clin. Oncol., December 1, 2004; 34(12): 707 - 716. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020