|
|
Blood, 1 July 2004, Vol. 104, No. 1, pp. 40-42.
Prepublished online as a Blood First Edition Paper on March 9, 2004; DOI 10.1182/blood-2003-10-3400.
 Previous Article | Next Article 
Submitted October 14, 2003
Accepted December 31, 2003
Acquired Fanconi Syndrome Is an Indolent Disorder in the Absence of Overt Multiple Myeloma
Cynthia X Ma, Martha Q Lacy*, John J Rompala, Angela Dispenzieri, S V Rajkumar, Philip R Greipp, Rafael Fonseca, Robert A Kyle, and Morie A Gertz
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA
* Corresponding author; email: lacy.martha{at}mayo.edu.
Adult-acquired Fanconi syndrome (FS) is a rare complication of monoclonal gammopathy. We retrospectively reviewed 32 patients diagnosed with adult-acquired FS between April 1968 and June 2002 at Mayo Clinic (Rochester, Minnesota). At diagnosis, most patients had monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM), with a median creatinine level of 2.0 mg/dL (range, 0.9-3.7 mg/dL) and evidence of osteomalacia. During the average 65 months (range, 2-238 months) of follow-up, 5 patients developed end-stage renal disease (ESRD) and only 1 of 14 patients with MGUS transformed to MM. Fourteen deaths occurred, with only 1 from ESRD but 4 from alkylator-related leukemia or myelodysplastic syndrome. Chemotherapy offered little benefit on renal functions of MGUS or SMM patients. In conclusion, FS associated with monoclonal gammopathy does not appear to confer an additional risk of subsequent evolution to MM. ESRD occurs late in the disease process.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
Best therapy for primary amyloidosis, a not-yet-solved question
- Arnaud Jaccard, Philippe Moreau, Veronique Leblond, and Jean-Paul Fermand
Blood 2004 104: 2990-2991.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
S C CHUA, S R O'CONNOR, W L WONG, and R H GANATRA
Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature
Br. J. Radiol.,
April 1, 2008;
81(964):
e110 - e114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Khoriaty, Z. K. Otrock, W. A. Medawar, R. B. Khauli, and A. Bazarbachi
A case of successful double sequential bone marrow and kidney transplantations in a patient with multiple myeloma
Nephrol. Dial. Transplant.,
December 1, 2006;
21(12):
3585 - 3588.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Gertz
Managing Myeloma Kidney
Ann Intern Med,
December 6, 2005;
143(11):
835 - 837.
[Full Text]
[PDF]
|
|
|
|
|
