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Blood, 1 August 2004, Vol. 104, No. 3, pp. 781-783. Prepublished online as a Blood First Edition Paper on April 6, 2004; DOI 10.1182/blood-2003-10-3468. This Article Full Text (PDF) All Versions of this Article: 2003-10-3468v1 104/3/781    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Shimizu, E. Articles by Taniguchi, M. Search for Related Content PubMed PubMed Citation Articles by Shimizu, E. Articles by Taniguchi, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 10, 2003 Accepted March 22, 2004 Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1 deficient mice Eiko Shimizu, Junzo Koike, Hiroshi Wakao, Ken-ichiro Seino, Haruhiko Koseki, Terutaka Kakiuchi, Toshinori Nakayama*, and Masaru Taniguchi Molecular Immunology, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan Molecular Embryology, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan; Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan Department of Immunology, Toho University School of Medicine, Ota-ku, Tokyo, Japan Medical Immunology, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan Molecular Immunology, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan; Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan * Corresponding author; email: nakayama{at}faculty.chiba-u.jp. Natural killer (NK) cells play a pivotal role in the immune reaction during the bone marrow allograft rejection. Little is known, however about the molecular mechanisms underlying the NK cell-mediated allograft recognition and rejection. In this report, we assessed the role of a recently identified NK receptor, KLRE-1, by generating knockout mice. KLRE-1-deficient mice were born at an expected frequency and showed no aberrant phenotype on growth and lymphoid development. Nevertheless, KLRE-1-deficient cells showed a severely compromised allogeneic cytotoxic activity as compared to the wild type cells. Furthermore, allogeneic bone marrow transfer culminated in colony formation in the spleen of KLRE-1-deficient mice, whereas no colony formation was observed in wild type recipient mice. These results demonstrate that KLRE-1 is a receptor mediating recognition and rejection of allogeneic target cells in the host immune system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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