SEARCH:   Advanced

Blood, 1 May 2004, Vol. 103, No. 9, pp. 3603-3605. Prepublished online as a Blood First Edition Paper on January 8, 2004; DOI 10.1182/blood-2003-10-3479. This Article Full Text (PDF) All Versions of this Article: 2003-10-3479v1 103/9/3603    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Woywodt, A. Articles by Haubitz, M. Search for Related Content PubMed PubMed Citation Articles by Woywodt, A. Articles by Haubitz, M. Social Bookmarking                   What's this? Submitted October 17, 2003 Accepted December 20, 2003 Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem-cell transplantation Alexander Woywodt*, Johanna Scheer, Lothar Hambach, Stefanie Buchholz, Arnold Ganser, Hermann Haller, Bernd Hertenstein, and Marion Haubitz Division of Nephrology, Hannover Medical School, Hannover, Germany Division of Nephrology, Hannover Medical School, Hannover, Germany; Division of Haematology/Oncology/Haemostaseology, Hannover Medical School, Hannover, Germany Division of Haematology/Oncology/Haemostaseology, Hannover Medical School, Hannover, Germany * Corresponding author; email: Woywodt.Alexander{at}mh-hannover. Damage to endothelial cells is the common feature of vascular disorders associated with hematopoietic stem-cell transplantation (HSCT). Elevated numbers of circulating endothelial cells reflect the extent of endothelial damage in a variety of disorders but their use in HSCT has not been investigated so far. We studied 39 patients undergoing allogeneic HSCT with different conditioning regimens and 22 healthy controls. Circulating endothelial cells were enumerated with immunomagnetic isolation during the course of HSCT. After conditioning, cell numbers were significantly elevated (median 44 cells/ml) compared to baseline (median 16 cells/ml) and controls (median 8 cells/ml). Patients who received radiation had an earlier peak when compared to patients with chemotherapy. Patients with reduced intensity conditioning had significantly lower cell numbers (median 24 cells/ml) than those who received standard conditioning. These observations provide a novel marker to investigate microvascular endothelial damage and the effects of different conditioning regimens in patients undergoing HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Woywodt, T. Kirsch, and M. Haubitz Circulating endothelial cells in renal disease: markers and mediators of vascular damage Nephrol. Dial. Transplant., January 1, 2008; 23(1): 7 - 10. [Full Text] [PDF] H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie Donor-derived cells and human graft-versus-host disease of the skin Blood, March 15, 2007; 109(6): 2663 - 2665. [Abstract] [Full Text] [PDF] G. Eissner, J. Wiesner, N. Hahn, M. Iacobelli, M. Haubitz, R. Andreesen, and E. Holler In Vitro Monitoring of Defibrotide Prophylaxis for Endothelial Complications Following Allogeneic Stem Cell Transplantation. Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): 2969 - 2969. [Abstract] [PDF] C. J. Boos, G. Y.H. Lip, and A. D. Blann Circulating Endothelial Cells in Cardiovascular Disease J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1538 - 1547. [Abstract] [Full Text] [PDF] G. M. Rigolin, C. Fraulini, M. Ciccone, E. Mauro, A. M. Bugli, C. De Angeli, M. Negrini, A. Cuneo, and G. Castoldi Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion Blood, March 15, 2006; 107(6): 2531 - 2535. [Abstract] [Full Text] [PDF] M. R. Cesarone, G. Belcaro, L. Pellegrini, A. Ledda, G. Vinciguerra, A. Ricci, G. Gizzi, E. Ippolito, F. Fano, M. Dugall, et al. Circulating Endothelial Cells in Venous Blood as a Marker of Endothelial Damage in Chronic Venous Insufficiency: Improvement with Venoruton Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2006; 11(1): 93 - 99. [Abstract] [PDF] A Woywodt, C Goldberg, T Kirsch, K de Groot, U Erdbruegger, H Haller, and M Haubitz Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis Ann Rheum Dis, February 1, 2006; 65(2): 164 - 168. [Abstract] [Full Text] [PDF] K. W.L. Yee, A. Hagey, S. Verstovsek, J. Cortes, G. Garcia-Manero, S. M. O'Brien, S. Faderl, D. Thomas, W. Wierda, S. Kornblau, et al. Phase 1 Study of ABT-751, a Novel Microtubule Inhibitor, in Patients with Refractory Hematologic Malignancies Clin. Cancer Res., September 15, 2005; 11(18): 6615 - 6624. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020