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Blood, 15 October 2004, Vol. 104, No. 8, pp. 2467-2474. Prepublished online as a Blood First Edition Paper on May 13, 2004; DOI 10.1182/blood-2003-10-3561. This Article Full Text (PDF) All Versions of this Article: 2003-10-3561v1 104/8/2467    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Castaigne, S. Articles by Dombret, H. Search for Related Content PubMed PubMed Citation Articles by Castaigne, S. Articles by Dombret, H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 20, 2003 Accepted March 31, 2004 Randomized comparison of double induction and timed-sequential induction to a "3+7" induction in adults with acute myeloid leukemia (AML). Long-term analysis of the Acute Leukemia French Association (ALFA) 9000 study Sylvie Castaigne*, Sylvie Chevret, Eric Archimbaud, Pierre Fenaux, Dominique Bordessoule, Herve Tilly, Thierry De Revel, Marc Simon, Brigitte Dupriez, Michel Renoux, Maud Janvier, Jean-Michel Miclea, Xavier Thomas, Christian Bastard, Claude Preudhomme, Francis Bauters, Laurent Degos, and Herve Dombret Hematology and Oncology, Centre Hospitalier de Versailles, Le Chesnay, France Biostatistics, Hopital Saint Louis, Paris, France Hematology, Hopital Edouard Herriot, Lyon, France Hematology, Centre Universitaire Regional Universitaire, Lille, France Hematology, Centre Hospitalier Regional Universitaire, Limoges, France Hematology, Centre Henri Becquerel, Rouen, France Hematology, Centre Hospitalier Inter Armees, Clamart, France Hematology, Centre Hospitalier, Lens, France Hematology, Centre Hospitalier, Valenciennes, France Hematology, Centre Hospitalier de la Cote Basque, Bayonne, France Hematology, Centre Rene Huguenin, Saint Cloud, France Hematology, Hopital Saint Louis, Paris, France * Corresponding author; email: scastaigne{at}ch-versailles.fr. Between 1990 and 1996, we conducted a randomized trial in adults with newlydiagnosed AML in order to compare relapse-free interval (RFI) after double induction (arm B), timed-sequential induction (arm C), or control "3+7" induction (arm A). Patients achieving complete remission (CR) after induction ± salvage received the same consolidation chemotherapy, which included a dosage stratification according to patient's age (less or older than 50 years). This long-term analysis was performed in 592 patients (arm A/B/C, 197/198/197 patients). Overall CR rate was 76% without differences between the three arms, even if a salvage course was less frequently needed in arm B. Treatment-related mortality, either during the induction or the post-remission phase, was not significantly higher in arms B and C than in arm A. Among the 449 CR patients, 250 relapsed (arm A/B/C, 90/87/73 patients) without significant differences in RFI in arms B and C versus arm A (P=.39 and .15, by the Gray test). However, when analyzing the 345 patients aged less than 50 years, RFI was significantly improved in younger patients receiving timed-sequential induction (P=.038 by the Gray test), while not in those receiving double induction. Event-free and overall survival were similar in the three randomization arms. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. B. Micol, N. Boissel, A. Renneville, S. Castaigne, C. Gardin, C. Preudhomme, and H. Dombret The role of cytogenetic abnormalities in acute myeloid leukemia with NPM1 mutations and no FLT3 internal tandem duplication Blood, November 12, 2009; 114(20): 4601 - 4602. [Full Text] [PDF] T. Prebet, N. Boissel, S. Reutenauer, X. Thomas, J. Delaunay, J.-Y. Cahn, A. Pigneux, B. Quesnel, F. Witz, S. Thepot, et al. 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Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG Blood, April 23, 2009; 113(17): 3903 - 3910. [Abstract] [Full Text] [PDF] B. D. Shah and J. E. Lancet Frontline Treatment of Acute Myeloid Leukemia: Are We Making Progress? ASCO Educational Book, January 1, 2009; 2009(1): 372 - 377. [Abstract] [Full Text] [PDF] W. P. Vaughan and J. E. Karp The Long Road to a Cure for Acute Myelocytic Leukemia: From Intensity to Specificity J. Clin. Oncol., July 20, 2008; 26(21): 3475 - 3477. [Full Text] [PDF] N. Boissel, A. Renneville, V. Biggio, N. Philippe, X. Thomas, J.-M. Cayuela, C. Terre, I. Tigaud, S. Castaigne, E. Raffoux, et al. Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype Blood, November 15, 2005; 106(10): 3618 - 3620. [Abstract] [Full Text] [PDF]

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