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Blood, 1 March 2005, Vol. 105, No. 5, pp. 2007-2015. Prepublished online as a Blood First Edition Paper on July 29, 2004; DOI 10.1182/blood-2003-10-3563. This Article Full Text (PDF) All Versions of this Article: 2003-10-3563v1 105/5/2007    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hall, A. M Articles by Barker, R. N Search for Related Content PubMed PubMed Citation Articles by Hall, A. M Articles by Barker, R. N Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 21, 2003 Accepted June 15, 2004 Rh Autoantigen presentation to helper T cells in chronic lymphocytic leukemia by malignant B-cells Andrew M Hall, Mark A Vickers, Ewan McLeod, and Robert N Barker* Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom * Corresponding author; email: r.n.barker{at}abdn.ac.uk. Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune diseases directed against constituents of the blood, including hemolytic anemia (AIHA). We hypothesized that CLL cells predispose to hematological autoimmunity by acting as aberrant antigen presenting cells (APC). Initially, it was confirmed that all studied patients with AIHA secondary to CLL harbored activated Th cells specific for epitopes on the dominant red blood cell (RBC) autoantigens in primary AIHA, the Rh proteins. Rh specific Th cells were also detected in a number of CLL patients who, although they did not suffer AIHA, had low levels of anti-RBC antibody in their serum. Fractionation of putative APC populations from the peripheral blood of patients by negative selection showed that CD5+ CLL cells are the most effective cell type in processing and presenting purified Rh protein to autoreactive Th cells. This ability was confirmed using positively selected CD5+ CLL cells. Thus, our study provides the first evidence for malignant cells driving an autoimmune response by acting as aberrant APC. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Galletti, C. Canones, P. Morande, M. Borge, P. Oppezzo, J. Geffner, R. Bezares, R. Gamberale, and M. Giordano Chronic Lymphocytic Leukemia Cells Bind and Present the Erythrocyte Protein Band 3: Possible Role as Initiators of Autoimmune Hemolytic Anemia J. Immunol., September 1, 2008; 181(5): 3674 - 3683. [Abstract] [Full Text] [PDF] C. Dearden, R. Wade, M. Else, S. Richards, D. Milligan, T. Hamblin, D. Catovsky, and for the UK National Cancer Research Institute (NCR The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia Blood, February 15, 2008; 111(4): 1820 - 1826. [Abstract] [Full Text] [PDF] J. Zou, S. Hannier, L. S. Cairns, R. N. Barker, A. J. Rees, A. N. Turner, and R. G. Phelps Healthy Individuals Have Goodpasture Autoantigen-Reactive T Cells J. Am. Soc. Nephrol., February 1, 2008; 19(2): 396 - 404. [Abstract] [Full Text] [PDF] S. Mittal, M. G. Blaylock, D. J. Culligan, R. N. Barker, and M. A. Vickers A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura Haematologica, January 1, 2008; 93(1): 151 - 152. [Abstract] [Full Text] [PDF] C. Dearden Disease-Specific Complications of Chronic Lymphocytic Leukemia Hematology, January 1, 2008; 2008(1): 450 - 456. [Abstract] [Full Text] [PDF]

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