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Blood, 15 April 2004, Vol. 103, No. 8, pp. 2873-2878. Prepublished online as a Blood First Edition Paper on December 24, 2003; DOI 10.1182/blood-2003-11-3800. This Article Full Text (PDF) All Versions of this Article: 2003-11-3800v1 103/8/2873    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kantarjian, H. Articles by Cortes, J. Search for Related Content PubMed PubMed Citation Articles by Kantarjian, H. Articles by Cortes, J. Related Collections Related Article in Blood Online Related Letter in Blood Online Social Bookmarking                   What's this? Submitted November 12, 2003 Accepted December 13, 2003 High-dose Imatinib Mesylate Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Chronic Phase Chronic Myeloid Leukemia Hagop Kantarjian*, Moshe Talpaz, Susan O'Brien, Guillermo Garcia-Manero, Srdan Verstovsek, Francis Giles, Mary Beth Rios, Jianqin Shan, Laurie Letvak, Deborah Thomas, Stefan Faderl, Allessandra Ferrajoli, and Jorge Cortes Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA Bioimmunotherapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA Global Phase IV-Glivec, Novartis Pharmacuticals Corporation, East Hanover, NJ, USA * Corresponding author; email: hkantarj{at}mdanderson.org. Imatinib mesylate (Gleevec; STI571) is effective in chronic phase chronic myelogenous leukemia (CML). However, most patients treated with imatinib 400 mg daily have variable levels of residual molecular disease. We treated 114 patients with newly diagnosed chronic phase CML with imatinib 400 mg twice daily. Overall, 109 patients (96%) had a major cytogenetic response (Ph < 35%), complete (Ph 0%) in 103 (90%). With a median follow-up of 15 months, no patient has progressed to accelerated or blastic phase. The estimated two-year survival rate was 94%. By quantitative polymerase chain reaction (QPCR) studies 71 of 112 patients (63%) showed BCR-ABL/ABL percentage ratios decrease to <0.05%, and 31 (28%) to undetectable levels. Compared with standard dose imatinib, high-dose imatinib was associated with significantly better complete cytogenetic response (p=0.0005), major molecular response (QPRC < 0.05%; p = 0.00001), and complete molecular response (undetectable BCR-ABL; p=0.001). High-dose imatinib was well tolerated but resulted in more frequent myelosuppression; 82% of patients continue to receive 600 mg of imatinib daily. In conclusion, high-dose imatinib induced higher rates of complete cytogenetic response and of molecular response in patients with newly diagnosed chronic phase CML. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Can we cure CML? Brian J. Druker Blood 2004 103: 2865-2866. [Full Text] [PDF] Related Letter in Blood Online: Discontinuation of imatinib therapy after achieving a molecular response Jorge Cortes, Susan O'Brien, and Hagop Kantarjian Blood 2004 104: 2204-2205. [Full Text] [PDF] This article has been cited by other articles: J. E. Cortes, H. M. Kantarjian, S. L. Goldberg, B. L. Powell, F. J. Giles, M. Wetzler, L. Akard, J. M. Burke, R. Kerr, M. Saleh, et al. High-Dose Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: High Rates of Rapid Cytogenetic and Molecular Responses J. Clin. Oncol., October 1, 2009; 27(28): 4754 - 4759. [Abstract] [Full Text] [PDF] E. Mattarucchi, O. Spinelli, A. Rambaldi, F. Pasquali, F. Lo Curto, L. Campiotti, and G. Porta Molecular Monitoring of Residual Disease in Chronic Myeloid Leukemia by Genomic DNA Compared with Conventional mRNA Analysis J. Mol. Diagn., September 1, 2009; 11(5): 482 - 487. [Abstract] [Full Text] [PDF] H. M. Kantarjian, J. Shan, D. Jones, S. O'Brien, M. B. Rios, E. Jabbour, and J. Cortes Significance of Increasing Levels of Minimal Residual Disease in Patients With Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia in Complete Cytogenetic Response J. Clin. Oncol., August 1, 2009; 27(22): 3659 - 3663. [Abstract] [Full Text] [PDF] A. Quintas-Cardama, H. Kantarjian, D. Jones, J. Shan, G. Borthakur, D. Thomas, S. Kornblau, S. O'Brien, and J. 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Hughes Measurement of In Vivo BCR-ABL Kinase Inhibition to Monitor Imatinib-Induced Target Blockade and Predict Response in Chronic Myeloid Leukemia J. Clin. Oncol., October 1, 2007; 25(28): 4445 - 4451. [Abstract] [Full Text] [PDF] C. A. Schiffer BCR-ABL Tyrosine Kinase Inhibitors for Chronic Myelogenous Leukemia N. Engl. J. Med., July 19, 2007; 357(3): 258 - 265. [Full Text] [PDF] H. Kantarjian, R. Pasquini, N. Hamerschlak, P. Rousselot, J. Holowiecki, S. Jootar, T. Robak, N. Khoroshko, T. Masszi, A. Skotnicki, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial Blood, June 15, 2007; 109(12): 5143 - 5150. [Abstract] [Full Text] [PDF] S. Picard, K. Titier, G. Etienne, E. Teilhet, D. Ducint, M.-A. Bernard, R. Lassalle, G. Marit, J. Reiffers, B. Begaud, et al. 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