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 Blood, 15 August 2004, Vol. 104, No. 4, pp. 1198-1200.
Prepublished online as a Blood First Edition Paper on April 27, 2004; DOI 10.1182/blood-2003-11-3884.

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Submitted November 13, 2003
Accepted April 6, 2004

The etiology of severe anemia in a village and a periurban area in Mali

Alassane Dicko, Amy D Klion, Mahmadou A Thera, Issaka Sagara, Daniel Yalcouye, Mohamed B Niambele, Moussa Sogoba, Guimogo Dolo, Adama Dao, Dapa A Diallo, Ogobara K Doumbo*, and Louis H Miller

Faculty of Medicine, Malaria Research and Training Center, University of Mali, Bamako, Mali
MVDB, NIAID, NIH, Rockville, MD, USA

* Corresponding author; email: okd{at}mrtcbko.org.

Severe anemia is one of the major complications of malaria in Africa. We studied two populations, one in a village and the second in a periurban area in Mali to understand the preventable factors in the disease. The two correlates of disease were parasitemia above 100,000 parasitized red blood cells per microL and low baseline hemoglobin. All cases of moderate to severe anemia occurred in children under 3.2 years of age. Raising baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection.


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