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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3697-3704. Prepublished online as a Blood First Edition Paper on August 3, 2004; DOI 10.1182/blood-2003-12-4114. This Article Full Text (PDF) All Versions of this Article: 2003-12-4114v1 104/12/3697    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Houde, C. Articles by Coignet, L. J Search for Related Content PubMed PubMed Citation Articles by Houde, C. Articles by Coignet, L. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 3, 2003 Accepted July 15, 2004 Over-expression of the NOTCH Ligand JAG2 in Malignant Plasma Cells from Multiple Myeloma Patients and Cell Lines Christiane Houde, Yulin Li, Lynda Song, Kevin Barton, Qing Zhang, John Godwin, Sucha Nand, Amir Toor, Serhan Alkan, N V Smadja, Herve Avet-Loiseau, Carmen S Lima, Lucio Miele, and Lionel J Coignet* Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA; Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Medicine, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA Cytogenetic Laboratory, Hopital St-Antoine, Paris, France Laboratoire d'Hematologie, Institut de Biologie, Nantes, France Hematology and Hemotherapy Center, State University of Campinas, Universitaria 'Zeferino Vaz', Campinas, Sao Paulo, Brazil Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA; Department of Medicine, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA; Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA * Corresponding author; email: lionel.coignet{at}roswellpark.org. The NOTCH ligand, JAG2, was found to be over-expressed in malignant plasma cells from Multiple Myeloma (MM) patients and cell lines but not in non-malignant plasma cells from tonsils, bone marrow from normal individuals, or patients with other malignancies. In addition, JAG2 over-expression was detected in 5/5 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS), an early phase of myeloma disease progression. This overexpression appears to be a consequence of hypomethylation of the JAG2 promoter in malignant plasma cells. An in vitro co-culture assay was used to demonstrate that JAG2 induced the secretion of IL6, VEGF and IGF1 in stromal cells. Further, the induction of IL6 secretion was blocked in vitro by interference with anti-Notch1 monoclonal antibodies raised against the binding sequence of Notch1 with JAG2. Taken together, these results indicate that JAG2 over-expression may be an early event in the pathogenesis of multiple myeloma involving IL-6 production. 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[Abstract] [Full Text] [PDF] L. Miele Notch Signaling Clin. Cancer Res., February 15, 2006; 12(4): 1074 - 1079. [Full Text] [PDF] B. Quesnel Multiple myeloma: all roads lead to cyclin D Blood, July 1, 2005; 106(1): 1 - 2. [Full Text] [PDF] A. A. Jungbluth, S. Ely, M. DiLiberto, R. Niesvizky, B. Williamson, D. Frosina, Y.-T. Chen, N. Bhardwaj, S. Chen-Kiang, L. J. Old, et al. The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation Blood, July 1, 2005; 106(1): 167 - 174. [Abstract] [Full Text] [PDF] T. Takeuchi, Y. Adachi, and Y. Ohtsuki Skeletrophin, a Novel Ubiquitin Ligase to the Intracellular Region of Jagged-2, Is Aberrantly Expressed in Multiple Myeloma Am. J. Pathol., June 1, 2005; 166(6): 1817 - 1826. [Abstract] [Full Text] [PDF] T. Matsumoto and M. Abe The Importance of Notch Signaling in Myeloma Cell-Osteoclast Interactions IBMS BoneKEy, February 1, 2005; 2(2): 7 - 10. [Full Text] [PDF]

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