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Blood, 1 August 2004, Vol. 104, No. 3, pp. 795-801. Prepublished online as a Blood First Edition Paper on April 13, 2004; DOI 10.1182/blood-2003-12-4175. This Article Full Text (PDF) All Versions of this Article: 2003-12-4175v1 104/3/795    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kohlhammer, H. Articles by Bentz, M. Search for Related Content PubMed PubMed Citation Articles by Kohlhammer, H. Articles by Bentz, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 5, 2003 Accepted March 1, 2004 Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions Holger Kohlhammer, Carsten Schwaenen, Swen Wessendorf, Karlheinz Holzmann, Hans A Kestler, Dirk Kienle, Thomas Barth, Peter Moller, German Ott, Jorg Kalla, Bernhard Radlwimmer, Armin Pscherer, Stephan Stilgenbauer, Hartmut Dohner, Peter Lichter, and Martin Bentz* Department of Internal Medicine III, University of Ulm, Ulm, Germany Department of Neuroinformatics, University of Ulm, Ulm, Germany; Department of Internal Medicine I, University of Ulm, Ulm, Germany Department of Pathology, University of Ulm, Ulm, Germany Department of Pathology, University of Wuerzburg, Wuerzburg, Germany Department of Molecular Genetics, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany * Corresponding author; email: martin.bentz{at}medizin.uni-ulm.de. Tumor samples of 53 patients with t(11;14)-positive MCLs were analyzed by matrix-based comparative genomic hybridization (Matrix-CGH) using a dedicated DNA-array. In 49 cases, genomic aberrations were identified. In comparison to chromosomal CGH, a 50% higher number of aberrations was found and the high specificity of Matrix-CGH was demonstrated by fluorescence in-situ hybridization (FISH) analyses. 11q gains and 13q34 deletions, which have not been described as frequent genomic aberrations in MCL, were identified by Matrix-CGH in 15 and 26 cases, respectively. For several genomic aberrations, novel consensus regions were defined: 8p21 (size of the consensus region 2.4 Mbp; candidate genes: TNFRSF10B, TNFRSF10C, TNFRSF10D); 10p13 (2.7 Mbp; BMI1); 11q13 (1.4 Mbp; RELA); 11q13 (5.2 Mbp; CCND1); 13q14 (0.4 Mbp; RFP2, BCMSUN) and 13q34 (6.9 Mbp). In univariate analyses correlating genomic aberrations and clinical course, 8p- and 13q14-deletions were associated with an inferior overall survival. These data provide a basis for further studies focussing on the identification of pathogenetically and/or clinically relevant genes in MCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Navarro, S. Bea, V. Fernandez, M. Prieto, I. Salaverria, P. Jares, E. Hartmann, A. Mozos, A. Lopez-Guillermo, N. Villamor, et al. MicroRNA Expression, Chromosomal Alterations, and Immunoglobulin Variable Heavy Chain Hypermutations in Mantle Cell Lymphomas Cancer Res., September 1, 2009; 69(17): 7071 - 7078. [Abstract] [Full Text] [PDF] S. Bea, I. Salaverria, L. Armengol, M. Pinyol, V. Fernandez, E. M. Hartmann, P. Jares, V. Amador, L. Hernandez, A. Navarro, et al. 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