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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1616-1623. Prepublished online as a Blood First Edition Paper on April 1, 2004; DOI 10.1182/blood-2003-12-4207. This Article Full Text (PDF) All Versions of this Article: 2003-12-4207v1 104/6/1616    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ho, A. Y Articles by Mufti, G. J Search for Related Content PubMed PubMed Citation Articles by Ho, A. Y Articles by Mufti, G. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 9, 2003 Accepted March 21, 2004 Reduced-intensity allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukaemia with multilineage dysplasia using Fludarabine, Busulphan and Alemtuzumab (CAMPATH-1H)(FBC) conditioning Aloysius Y Ho, Antonio Pagliuca, Michelle Kenyon, Jane E Parker, Aleksandar Mijovic, Stephen Devereux, and Ghulam J Mufti* Department of Haematological Medicine, King's College Hospital, London, United Kingdom * Corresponding author; email: ghulam.mufti{at}kcl.ac.uk. Reduced-intensity conditioned haematopoietic stem cell transplantation has improved the accessibility of transplantation in patients previously ineligible. We report the results of allografting following conditioning with fludarabine, busulphan and alemtuzumab in 62 patients with myelodysplastic syndromes (MDS) [matched sibling donors (24) or volunteer unrelated donors (VUD)(38)]. The median age for sibling recipients was 56 years (41-70) and for VUD recipients 52 years (22-65) with a median follow-up (survivors) of 524 days (93-1392) and 420 days (53-1495) respectively. The non-relapse mortality (NRM) at Day 100, 200 and 360 was 0%, 5% and 5% respectively for siblings; 11%, 17% and 21% for VUD. The overall survival at one year was 73% for siblings, 71% for VUD, with a disease free survival (DFS) of 61% and 59% respectively. The prognostic significance of the IPSS was preserved. 86% of recipients achieved full donor chimerism. The cumulative incidence at Day 100 of Grade III-IV GvHD for VUD recipients was 9% and for sibling recipients 0%. 26 patients (16 sibling & 10 VUD) received DLI at a median of 273 days (126-1323). RIC allogeneic HSCT using this protocol appears to be safe and permits durable donor engraftment. Longer follow-up is required to confirm any potential survival advantage. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Marks, K. Potthoff, J. Hahn, G. Ihorst, H. Bertz, A. Spyridonidis, E. Holler, and J. M. Finke Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies Blood, July 15, 2008; 112(2): 415 - 425. [Abstract] [Full Text] [PDF] D. Valcarcel, R. Martino, D. Caballero, J. Martin, C. Ferra, J. B. Nieto, A. Sampol, M. T. Bernal, J. L. Pinana, L. Vazquez, et al. Sustained Remissions of High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome After Reduced-Intensity Conditioning Allogeneic Hematopoietic Transplantation: Chronic Graft-Versus-Host Disease Is the Strongest Factor Improving Survival J. Clin. Oncol., February 1, 2008; 26(4): 577 - 584. [Abstract] [Full Text] [PDF] N. Omidvar, S. Kogan, S. Beurlet, C. le Pogam, A. Janin, R. West, M.-E. Noguera, M. Reboul, A. Soulie, C. Leboeuf, et al. BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia Cancer Res., December 15, 2007; 67(24): 11657 - 11667. [Abstract] [Full Text] [PDF] A. A. Jakubowski, T. N. Small, J. W. Young, N. A. Kernan, H. Castro-Malaspina, K. C. Hsu, M.-A. Perales, N. Collins, C. Cisek, M. Chiu, et al. 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