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Blood, 1 October 2004, Vol. 104, No. 7, pp. 2010-2019. Prepublished online as a Blood First Edition Paper on June 22, 2004; DOI 10.1182/blood-2003-12-4219. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2003-12-4219v1 104/7/2010    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hildbrand, P. Articles by Crisa, L. Search for Related Content PubMed PubMed Citation Articles by Hildbrand, P. Articles by Crisa, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 11, 2003 Accepted May 3, 2004 The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors Patrick Hildbrand, Vincenzo Cirulli, Prinsen C Robyn, Kent A Smith, Bruce E Torbett, Daniel R Salomon, and Laura Crisa* Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA Pediatrics, University of California, La Jolla, CA, USA Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA; Immunology, The Scripps Research Institute, La Jolla, CA, USA * Corresponding author; email: crisa{at}scripps.edu. Circulating endothelial progenitors have been shown to contribute to neo-vascularization at sites of injury and tumorogenesis in post-natal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from progenitors circulating in human cord blood requires angiopoietins, a set of growth factors also involved in vascular branching during embryogenesis. We show that cord blood cells with the potential for endothelial development reside in a CD34+CD11b+ subset capable of autonomously producing and binding angiopoietins. Functionally, endogenous angiopoietin-1 regulates initial endothelial cell commitment, whereas angiopoietin-2 enhances expansion of the endothelial cell progeny. These findings suggest a role for angiopoietins as regulators of endothelial development from circulating progenitors, and imply a function of angiopoietins at distinct developmental steps in post-natal angiogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Tian, P. H. Liang, and L.-Y. 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