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Blood, 15 October 2004, Vol. 104, No. 8, pp. 2235-2246. Prepublished online as a Blood First Edition Paper on July 1, 2004; DOI 10.1182/blood-2003-12-4392. This Article Full Text (PDF) All Versions of this Article: 2003-12-4392v1 104/8/2235    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by O'Neill, D. W Articles by Bhardwaj, N. Search for Related Content PubMed PubMed Citation Articles by O'Neill, D. W Articles by Bhardwaj, N. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 24, 2003 Accepted June 2, 2004 Manipulating dendritic cell biology for the active immunotherapy of cancer David W O'Neill, Sylvia Adams, and Nina Bhardwaj* NYU Cancer Institute Tumor Vaccine Center, New York University School of Medicine, New York, NY, USA * Corresponding author; email: nina.bhardwaj{at}med.nyu.edu. Dendritic cells (DCs) are specialized antigen presenting cells (APCs) that have an unequalled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the development of potent immunotherapies for cancer, chronic infections, autoimmune disease and induction of transplantation tolerance. This review discusses recent advances in DC research and the application of this knowledge towards new strategies for the clinical manipulation of DCs for cancer immunotherapy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R.-I. You, Y.-C. Chang, P.-M. Chen, W.-S. Wang, T.-L. Hsu, C.-Y. Yang, C.-T. Lee, and S.-L. Hsieh Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3) Blood, February 1, 2008; 111(3): 1480 - 1488. [Abstract] [Full Text] [PDF] T. L. Papenfuss, A. P. Kithcart, N. D. Powell, M. A. McClain, I. E. Gienapp, T. M. Shawler, and C. C. Whitacre Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis J. Leukoc. Biol., December 1, 2007; 82(6): 1510 - 1518. [Abstract] [Full Text] [PDF] L. J. Young, N. S. Wilson, P. Schnorrer, A. Mount, R. J. Lundie, N. L. La Gruta, B. S. Crabb, G. T. Belz, W. R. Heath, and J. A. 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