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Blood, 15 January 2005, Vol. 105, No. 2, pp. 855-861. Prepublished online as a Blood First Edition Paper on July 15, 2004; DOI 10.1182/blood-2004-01-0177. This Article Full Text (PDF) All Versions of this Article: 2004-01-0177v1 105/2/855    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by St. Pierre, T. G Articles by Lindeman, R. Search for Related Content PubMed PubMed Citation Articles by St. Pierre, T. G Articles by Lindeman, R. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 15, 2004 Accepted July 2, 2004 Non-Invasive Measurement and Imaging of Liver Iron Concentrations Using Proton Magnetic Resonance Timothy G St. Pierre*, Paul R Clark, Wanida Chua-anusorn, Adam J Fleming, Gary P Jeffrey, John K Olynyk, Pensri Pootrakul, Erin Robins, and Robert Lindeman School of Physics, University of Western Australia, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Thalassemia Research Center, Mahidol University, Bangkok, Nakornpathom, Thailand SKG Radiology, St John of God Hospital, Perth, Western Australlia, Australia Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales, Australia * Corresponding author; email: stpierre{at}physics.uwa.edu.au. Measurement of liver iron concentrations (LIC) is necessary for a range of iron loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study presents a readily available non-invasive method of measuring and imaging LIC in vivo using clinical 1.5 T magnetic resonance imaging units. Mean liver proton transverse relaxation rates (R2) were measured for 105 human subjects. A value for the LIC for each subject was obtained by chemical assay of a needle biopsy specimen. High degrees of sensitivity and specificity of R2 to biopsy LIC were found at the clinically significant LIC thresholds of 1.8, 3.2, 7.0 and 15.0 mg Fe/g dry tissue. A calibration curve relating liver R2 to LIC has been deduced from the data covering the range of LIC from 0.3 to 42.7 mg Fe/g dry tissue. Proton transverse relaxation rates in aqueous paramagnetic solutions were also measured on each magnetic resonance imaging unit to ensure instrument-independent results. Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Liver iron measurement by MRI John B. Porter Blood 2005 105: 437-438. [Full Text] [PDF] This article has been cited by other articles: T. V. Adamkiewicz, M. R. Abboud, C. Paley, N. Olivieri, M. Kirby-Allen, E. Vichinsky, J. F. Casella, O. A. Alvarez, J. C. Barredo, M. T. Lee, et al. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury Blood, November 19, 2009; 114(21): 4632 - 4638. [Abstract] [Full Text] [PDF] H. 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