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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1656-1661. Prepublished online as a Blood First Edition Paper on June 1, 2004; DOI 10.1182/blood-2004-01-0247. This Article Full Text (PDF) All Versions of this Article: 2004-01-0247v1 104/6/1656    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morii, E. Articles by Kitamura, Y. Search for Related Content PubMed PubMed Citation Articles by Morii, E. Articles by Kitamura, Y. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 21, 2004 Accepted May 10, 2004 Roles of MITF for Development of Mast Cells in Mice: Effects on Both Precursors and Tissue Environments Eiichi Morii*, Keisuke Oboki, Katsuhiko Ishihara, Tomoko Jippo, Toshio Hirano, and Yukihiko Kitamura Pathology, Osaka Univerisity Medical School, Suita, Osaka, Japan Molecular Oncology, Osaka Univerisity Medical School, Suita, Osaka, Japan Physiology, Senri Kinran University Faculty of Human Life Sciences, Suita, Osaka, Japan * Corresponding author; email: morii{at}patho.med.osaka-u.ac.jp. The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that thetg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examined this possibility by bone marrow and skin transplantation. When bone marrow cells of tg/tg mice were transplanted to W/Wv mice that possess normal tissue environment, mast cells did not develop in all tissues examined. The number of developing mast cells in the skin of W/Wv mice was much lower when grafted to tg/tg recipients than when grafted to normal (+/+) recipients. These results indicated that mast cell precursors of tg/tg mice were defective. When bone marrow cells of +/+ mice were transplanted, the number of developing mast cells was significantly lower in examined tissues of tg/tg recipients than in those of W/Wv recipients, suggesting that the tissue environment for mast cell development was defective in tg/tg mice. MITF appeared essential for the function of both mast cell precursors and tissue environments for their development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. D. Dyer, M. Czapiga, B. Foster, P. S. Foster, E. M. Kang, C. M. Lappas, J. M. Moser, N. Naumann, C. M. Percopo, S. J. Siegel, et al. Eosinophils from Lineage-Ablated {Delta}dblGATA Bone Marrow Progenitors: The dblGATA Enhancer in the Promoter of GATA-1 Is Not Essential for Differentiation Ex Vivo J. Immunol., August 1, 2007; 179(3): 1693 - 1699. [Abstract] [Full Text] [PDF] S. M. Thakurdas, E. Melicoff, L. Sansores-Garcia, D. C. Moreira, Y. Petrova, R. L. Stevens, and R. Adachi The Mast Cell-restricted Tryptase mMCP-6 Has a Critical Immunoprotective Role in Bacterial Infections J. Biol. Chem., July 20, 2007; 282(29): 20809 - 20815. [Abstract] [Full Text] [PDF] H. P. McNeil, R. Adachi, and R. L. Stevens Mast Cell-restricted Tryptases: Structure and Function in Inflammation and Pathogen Defense J. Biol. Chem., July 20, 2007; 282(29): 20785 - 20789. [Abstract] [Full Text] [PDF] L. Chin, L. A. Garraway, and D. E. Fisher Malignant melanoma: genetics and therapeutics in the genomic era. Genes & Dev., August 15, 2006; 20(16): 2149 - 2182. [Abstract] [Full Text] [PDF] E. Morii and K. Oboki MITF Is Necessary for Generation of Prostaglandin D2 in Mouse Mast Cells J. Biol. Chem., November 19, 2004; 279(47): 48923 - 48929. [Abstract] [Full Text] [PDF]

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