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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1801-1807. Prepublished online as a Blood First Edition Paper on June 3, 2004; DOI 10.1182/blood-2004-01-0331. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-01-0331v1 104/6/1801    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by ANGELINI, D. F Articles by BATTISTINI, L. Search for Related Content PubMed PubMed Citation Articles by ANGELINI, D. F Articles by BATTISTINI, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 28, 2004 Accepted May 3, 2004 FcRIII discriminates between two subsets of V9V2 effector cells with different responses and activation pathways Daniela F ANGELINI, Giovanna BORSELLINO, Mary POUPOT, Adamo DIAMANTINI, Remy POUPOT, Giorgio BERNARDI, Fabrizio POCCIA, Jean-Jacques FOURNIE, and Luca BATTISTINI* Neuroimmunology Unit, Santa Lucia Foundation Scientific Institute IRCCS, Rome, Italy Department of Oncogenese & Signalisation dans les Cellules Hematopoietiques,, Institut National de la Sante et de la Recherche Medicale, Centre de Physiopathologie de Toulouse Purpan, Tolouse, France Neuroscience, University of Rome Tor Vergata,, Rome, Italy Immunopathology, National Institute for Infectious Diseases, Spallanzani IRCCS, Rome, Italy * Corresponding author; email: l.battistini{at}hsantalucia.it. Upon recognition of nonpeptidic phosphoantigens, human V2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory V2 population, two distinct and complementary subsets with regard to phenotype, mode of activation and type of responses can be identified: V2TEMh cells, which express high levels of chemokine receptors, but low levels of perforin and of NK receptors (NKRs) and which produce large amounts of IFN- and TNF- in response to TCR-specific stimulation by phosphoantigens; and V2TEMRA cells, which constitutively express several NKRs, high amounts of perforin, but low levels of chemokine receptors and of IFN-. These NK-like cells are refractory to phosphoantigen but respond to activation via FcRIII (CD16) and are highly active against tumoral target cells. 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