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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2410-2414. Prepublished online as a Blood First Edition Paper on October 12, 2004; DOI 10.1182/blood-2004-01-0348. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-01-0348v1 105/6/2410    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kalina, T. Articles by Storek, J. Search for Related Content PubMed PubMed Citation Articles by Kalina, T. Articles by Storek, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 28, 2004 Accepted September 5, 2004 De novo generation of CD4 T cells against viruses present in the host during immune reconstitution Tomas Kalina, Hailing Lu, Zhao Zhao, Earl Blewett, Dirk P Dittmer, Julie Randolph-Habecker, David G Maloney, Robert G Andrews, Hans-Peter Kiem, and Jan Storek* Fred Hutchinson Cancer Research Center and University of Washington School of Medicine, Seattle, WA, USA; 2nd Medical School, Charles University, Prague, Czech Republic Fred Hutchinson Cancer Research Center and University of Washington School of Medicine, Seattle, WA, USA Oklahoma State University College of Osteopathic Medicine, Tulsa, OK, USA University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA * Corresponding author; email: jstorek{at}ucalgary.ca. T cells recognizing self-peptides are typically deleted in the thymus by negative selection. It is not known whether T cells against persistent viruses (e.g., herpesviruses) are generated by the thymus (de novo) after the onset of the infection. Peptides from such viruses might be considered by the thymus as self-peptides, and T cells specific for these peptides might be deleted (negatively selected). Here we demonstrate in baboons infected with baboon cytomegalovirus and baboon lymphocryptovirus (Epstein-Barr virus-like virus) that after autologous transplantation of yellow fluorescent protein (YFP)-marked hematopoietic cells, YFP+ CD4 T cells against these viruses were generated de novo. Thus the thymus generates CD4 T cells against not only pathogens absent from the host but also pathogens present in the host. This finding provides a strong rationale to improve thymopoiesis in hematopoietic cell transplant recipients and, perhaps, also in other individuals lacking de novo generated CD4 T cells like AIDS patients and elderly persons. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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