SEARCH:   Advanced

Blood, 15 November 2004, Vol. 104, No. 10, pp. 3343-3348. Prepublished online as a Blood First Edition Paper on July 15, 2004; DOI 10.1182/blood-2004-01-0385. This Article Full Text (PDF) All Versions of this Article: 2004-01-0385v1 104/10/3343    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Attygalle, A. D Articles by Isaacson, P. G Search for Related Content PubMed PubMed Citation Articles by Attygalle, A. D Articles by Isaacson, P. G Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 30, 2004 Accepted June 30, 2004 Atypical marginal zone hyperplasia of mucosa associated lymphoid tissue:a reactive condition of childhood showing immunoglobulin lambda light chain restriction Ayoma D Attygalle, Hongxiang Liu, Sima Shirali, Timothy C Diss, Christoph Loddenkemper, Harald Stein, Ahmet Dogan, Ming-Qing Du, and Peter G Isaacson* Department of Histopathology, Royal Free and University College Medical School, London, United Kingdom Department of Pathology, University of Cambridge, Cambridge, United Kingdom Institute of Pathology, Benjamin Franklin University Hospital, Free University, Berlin, Germany * Corresponding author; email: p.isaacson{at}ucl.ac.uk. MALT lymphomas usually arise at sites of acquired MALT, and are uncommon in native MALT (e.g. Peyer's patches and tonsil). Malignancy in these low-grade lymphomas is often inferred by immunoglobulin light chain restriction and expression of CD43; molecular genetic evidence is sought only if these are in doubt. We report 6 cases (4 tonsils, 2 appendices) of marginal zone (MZ) hyperplasia in children aged 3-11 years, that, despite histological and immunophenotypic features indicative of lymphoma, were polyclonal by molecular analysis. No lymphoma directed therapy was given and patients remain alive and well (5 cases, median follow up 35.3 months). The involved tonsil and appendix showed florid MZ hyperplasia with prominent intra-epithelial B-cells (IEBC). The MZ and IEBC showed a high proliferation fraction and a CD20+, CD21+, CD27-, IRTA-1+, CD43+, MUM-1, IgM+D+ phenotype. PCR, cloning and sequencing of rearranged IgH and Ig genes (whole tissue sections [6 cases]; microdissected cells [2 cases]) showed that the MZ B-cells and IEBC were polyclonal and the IgH genes non-mutated. In contrast, marginal zone (intraepithelial) B-cells of 6 control tonsils had a similar immunophenotype, except for expression of CD27 and polytypic light chains while molecular studies showed that they were polyclonal with mutated Ig genes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Onciu The Pathologist's Perspective on Challenging Pediatric Lymphomas: Update on the Pathobiology of Uncommon Childhood Lymphomas ASCO Educational Book, January 1, 2009; 2009(1): 604 - 607. [Abstract] [Full Text] [PDF] F. E. Craig and K. A. Foon Flow cytometric immunophenotyping for hematologic neoplasms Blood, April 15, 2008; 111(8): 3941 - 3967. [Abstract] [Full Text] [PDF] G. R.A. Ehrhardt, J. T. Hsu, L. Gartland, C.-M. Leu, S. Zhang, R. S. Davis, and M. D. Cooper Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells J. Exp. Med., September 19, 2005; 202(6): 783 - 791. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020